Loading...
Please wait, while we are loading the content...
Similar Documents
Evaluation and comparison of expression of p63 in odontogenic keratocyst, solid ameloblastoma and unicystic ameloblastoma
| Content Provider | Scilit |
|---|---|
| Author | Varsha, Bk Gharat, A. Leena Nagamalini, Br Jyothsna, M. Mothkur, Sahana T. Swaminathan, Uma |
| Copyright Year | 2014 |
| Abstract | Background and Objectives: The behavior of odontogenic lesions varies with some tumors behaving like a cyst and some cysts behaving like tumors. p63, a member of the p53 family of tumor suppressor genes has recently come into light in view of its role as an oncogene. The aim of the present study was to investigate the expression of p63 protein in OKC, Solid ameloblastoma, Unicystic Ameloblastoma and Follicular tissue. Materials and Methods: p63 expression was compared in 12 cases of OKC, 12 Solid Ameloblastoma, 14 cases of Unicystic ameloblastoma and 10 cases of Follicular tissue using immunohistochemical technique. All 48 cases were subjected to heat-induced antigen retrieval method using citrate buffer in a pressure cooker. Then the sections were stained with anti-p63 polyclonal antibody and visualized using super sensitive polymer HRP detection system. In each case, number of cells showing p63 positivity were assessed in two compartments - basal and suprabasal and compared. Results: Statistical analysis showed that p63 expression in the suprabasal compartment in Odontogenic keratocysts was equivalent to that of central neoplastic cells of Solid Ameloblastoma and Unicystic Ameloblastoma type 3. Statistically significant difference in the expression of p63 was observed between OKC and Unicystic Ameloblastoma Type 1 and Solid Ameloblastoma and Unicystic Ameloblastoma Type 1. Conclusion: We conclude that the higher expression of p63 in these odontogenic lesions correlates well with their aggressive behavior and thereby suggesting alterations in treatment modalities. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196291/pdf https://www.jomfp.in/article.asp?issn=0973-029X;year=2014;volume=18;issue=2;spage=223;epage=228;aulast=Varsha;type=2 |
| Ending Page | 228 |
| Page Count | 6 |
| Starting Page | 223 |
| File Format | XHTML |
| ISSN | 0973029X |
| e-ISSN | 1998393X |
| DOI | 10.4103/0973-029x.140755 |
| Journal | Journal of Oral and Maxillofacial Pathology |
| Issue Number | 2 |
| Volume Number | 18 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Microscopic Research Immunohistochemistry Odontogenic Keratocyst Solid Ameloblastoma Unicystic Ameloblastoma Journal of Oral and Maxillofacial Pathology, Volume 18, Issue 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dentistry Otorhinolaryngology Pathology and Forensic Medicine |
