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The efficacy of intravitreal dexamethasone implant as the first-line treatment for retinal vein occlusion-related macular edema in a real-life scenario
| Content Provider | Scilit |
|---|---|
| Author | Ozates, Serdar Ozkoyuncu, Dilara Simsek, Mert Citirik, Mehmet |
| Copyright Year | 2018 |
| Abstract | Purpose: This study evaluated the effect of intravitreal dexamethasone implant (IDI; Ozurdex) injection for treating macular edema in patients with branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Methods: This prospective study included 40 eyes of 40 patients with nonischemic BRVO and 31 eyes of 31 patients with nonischemic CRVO who received IDI injection as the first-line treatment for macular edema. The best-corrected visual acuity (BCVA) value before and after the treatment; intraocular pressure; optic coherence tomography findings; and all ocular examination findings, including central foveal thickness (CFT) measurement and fluorescein angiography findings, were evaluated for each patient. Results: After the IDI injection, BCVA value increased (P < 0.001) and CFT value decreased (P < 0.001) in both groups. The recurrence rates of CFT elevation after the first and the second Ozurdex injections were 65.0% and 65.3%, respectively, in patients with BRVO and 70.9% and 68.1%, respectively, in patients with CRVO. A statistically significant correlation was observed between preinjection CFT value and postinjection recurrence of CFT elevation (P = 0.017). Conclusion: Treatment with the IDI injections resulted in significant short-term improvement in CFT and BCVA values in patients with clinically significant RVO-related macular edema. Moreover, we observed that high preinjection CFT value was associated with a risk of postinjection recurrence of CFT elevation. |
| Related Links | http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=6;spage=831;epage=836;aulast=Simsek;type=2 |
| Ending Page | 836 |
| Page Count | 6 |
| Starting Page | 831 |
| File Format | XHTML |
| ISSN | 03014738 |
| e-ISSN | 19983689 |
| DOI | 10.4103/ijo.ijo_1259_17 |
| Journal | Indian Journal of Ophthalmology |
| Issue Number | 6 |
| Volume Number | 66 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2018-01-01 |
| Access Restriction | Open |
| Subject Keyword | Rehabilitation Branch Retinal Vein Occlusion Central Retinal Vein Occlusion Dexamethasone Implant Macular Edema Ozurdex Implant Indian Journal of Ophthalmology, Volume 66, Issue 6 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
