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Do corticosteroids play a role in the management of traumatic brain injury?
| Content Provider | Scilit |
|---|---|
| Author | Hoshide, Reid Cheung, Vincent Marshall, Lawrence Kasper, Ekkehard Chen, Clark C. |
| Copyright Year | 2016 |
| Abstract | Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025911/pdf |
| File Format | XHTML |
| ISSN | 21527806 |
| e-ISSN | 21527806 |
| DOI | 10.4103/2152-7806.190439 |
| Journal | Surgical Neurology International |
| Issue Number | 1 |
| Volume Number | 7 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology Outcomes Randomized Controlled Trials Steroids Traumatic Brain Injury Surgical Neurology International, Volume 7, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology (clinical) Surgery |
