NDLI: ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders

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ABC efflux transporters at blood-central nervous system barriers and their implications for treating spinal cord disorders

Content Provider	Scilit
Author	Koehn, Liam M.
Copyright Year	2020
Abstract	The barriers present in the interfaces between the blood and the central nervous system form a major hurdle for the pharmacological treatment of central nervous system injuries and diseases. The family of ATP-binding cassette (ABC) transporters has been widely studied regarding efflux of medications at blood-central nervous system barriers. These efflux transporters include P-glycoprotein (abcb1), ‘breast cancer resistance protein’ (abcg2) and the various ‘multidrug resistance-associated proteins’ (abccs). Understanding which efflux transporters are present at the blood-spinal cord, blood-cerebrospinal fluid and cerebrospinal fluid-spinal cord barriers is necessary to determine their involvement in limiting drug transfer from blood to the spinal cord tissue. Recent developments in the blood-brain barrier field have shown that barrier systems are dynamic and the profile of barrier defenses can alter due to conditions such as age, disease and environmental challenge. This means that a true understanding of ABC efflux transporter expression and localization should not be one static value but instead a range that represents the complex patient subpopulations that exist. In the present review, the blood-central nervous system barrier literature is discussed with a focus on the impact of ABC efflux transporters on: (i) protecting the spinal cord from adverse effects of systemically directed drugs, and (ii) limiting centrally directed drugs from accessing their active sites within the spinal cord.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047801/pdf
Ending Page	1242
Page Count	8
Starting Page	1235
File Format	XHTML
ISSN	16735374
DOI	10.4103/1673-5374.272568
Journal	Neural Regeneration Research
Issue Number	7
Volume Number	15
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Geriatrics Pharmacology and Pharmacy Abc Transporters Atp-binding Cassette Bcrp Blood-brain Barrier Blood-spinal Cord Barrier Efflux Mrp P-glycoprotein Pgp Spinal Cord Injury Neural Regeneration Research, Volume 15, Issue 7
Content Type	Text
Resource Type	Article
Subject	Developmental Neuroscience

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