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Perinatal transmission of Hepatitis B
| Content Provider | Scilit |
|---|---|
| Author | Chowdhury, Sudipta Dhar Eapen, C. E. |
| Copyright Year | 2009 |
| Abstract | There is a high global prevalence of hepatitis B. Perinatal transmission of hepatitis B is the predominant mode of transmission in high prevalence areas. The risk of progression to chronic liver disease and development of hepatocellular carcinoma in individuals who acquire the infection at birth is high. Perinatal transmission of hepatitis B can be reduced by early identification of hepatitis B virus (HBV) carrier mothers. High maternal viral loads and maternal serum HBeAg positivity increase the risk of perinatal transmission of hepatitis B. Passive and active immunoprophylaxis at birth reduces the risk of perinatal transmission of hepatitis B in approximately 95%. Failure of immunoprophylaxis has been related to possible in utero transmission of HBV. Reducing maternal HBV DNA levels by treatment with lamivudine in the last trimester of pregnancy in high viremic mothers may help reduce the risk of perinatal transmission of hepatitis B. |
| Related Links | http://www.hepatitisbannual.org/article.asp?issn=0972-9747;year=2009;volume=6;issue=1;spage=80;epage=88;aulast=Chowdhury;type=2 |
| File Format | XHTML |
| ISSN | 09729747 |
| DOI | 10.4103/0972-9747.76906 |
| Journal | Hepatitis B Annual |
| Issue Number | 1 |
| Volume Number | 6 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Gastroenterology and Hepatology Hepatitis B Immunoprophylaxis Transmission Hepatitis B Annual, Volume 6, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Hepatology |
