Loading...
Please wait, while we are loading the content...
Similar Documents
Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone for postoperative nausea and vomiting in postchemotherapy ovarian cancer surgeries requiring opioid-based patient-controlled analgesia: A randomised, double-blind, active controlled study
| Content Provider | Scilit |
|---|---|
| Author | Solanki, Sohan Lal Kumar, Amit Gangakhedkar, Gauri Raman Shylasree, Ts Sharma, Kailash S. |
| Copyright Year | 2018 |
| Abstract | Background and Aims: Patients undergoing ovarian cancer surgery after chemotherapy and requiring opioid-based patient-controlled analgesia (PCA) are at high-risk of postoperative nausea and vomiting (PONV). We aimed to assess the effect of palonosetron and dexamethasone combination for these patients for prevention of PONV. Methods: This study included 2 groups and 150 patients. At the time of wound closure, patients in group A received ondansetron 8 mg intravenous (IV) + dexamethasone 4 mg IV and group B received palonosetron 0.075 mg IV + dexamethasone 4 mg IV. Postoperatively for 48 hours, group A patients received ondansetron 4 mg 8 hourly IV, group B patients received normal saline 8 hourly IV in 2 cc syringe. The primary objective was the overall incidence of PONV. Independent t-test, Chi-square test, and Fisher's exact test were used and multivariate regression analysis was done. Results: Vomiting was significantly higher in group A (37.3%) as compared with group B (21.3%) at 0–48 hours (P = 0.031). Significantly more patients in Group A had nausea as compared with group B at 90–120 minutes (30.66% vs 18.66%, P = 0.043) and 6–24 hours (32.0% vs 22.66%, P = 0.029). PCA opioid usage in microgram was significantly higher in group A at 0–24 hours (690.53 ± 332.57 vs 576.85 ± 250.79, P = 0.024) and 0–48 hours (1126.10 ± 512.18 vs 952.13 ± 353.85, P = 0.030). Conclusion: Palonosetron with dexamethasone is more effective than ondasetron with dexamethasone for prevention of PONV in post-chemotherapy ovarian cancer surgeries receiving opioid-based patient controlled analgesia. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190431/pdf |
| Ending Page | 779 |
| Page Count | 7 |
| Starting Page | 773 |
| File Format | XHTML |
| ISSN | 00195049 |
| e-ISSN | 09762817 |
| DOI | 10.4103/ija.ija_437_18 |
| Journal | Indian Journal of Anaesthesia |
| Issue Number | 10 |
| Volume Number | 62 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2018-01-01 |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology Ondansetron Ovarian Neoplasm Palonosetron Postoperative Nausea and Vomiting Indian Journal of Anaesthesia, Volume 62, Issue 10 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
