NDLI: Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats

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Schwann cells originating from skin-derived precursors promote peripheral nerve regeneration in rats

Content Provider	Scilit
Author	Chen, Jianghai Chen, Zhenbing Zhang, Ping Lu, Xiaocheng
Copyright Year	2014
Abstract	Artificial guidance channels containing Schwann cells can promote the regeneration of injured peripheral nerve over long distances. However, primary Schwann cells are not suitable for autotransplantation. Under specific conditions, skin-derived progenitors can be induced to differentiate into Schwann cells. Therefore, adult rat dorsal skin (dermis)-derived progenitors were isolated and induced to differentiate with DMEM/F12 containing B27, neuregulin 1, and forskolin. Immunofluorescence staining and reverse transcription polymerase chain reaction (RT-PCR) confirmed that the resultant cells were indeed Schwann cells. Artificial guidance channels containing skin-derived progenitors, Schwann cells originating from skin-derived progenitors, or primary Schwann cells were used to bridge 5 mm sciatic nerve defects. Schwann cells originating from skin-derived progenitors significantly promoted sciatic nerve axonal regeneration. The significant recovery of injured rat sciatic nerve function after the transplantation of Schwann cells originating from skin-derived progenitors was confirmed by electromyogram. The therapeutic effect of Schwann cells originating from skin-derived progenitors was better than that of skin-derived progenitors. These findings indicate that Schwann cells originating from skin-derived precursors can promote peripheral nerve regeneration in rats.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211190/pdf
Ending Page	1702
Page Count	7
Starting Page	1696
File Format	XHTML
ISSN	16735374
DOI	10.4103/1673-5374.141805
Journal	Neural Regeneration Research
Issue Number	18
Volume Number	9
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Biochemistry and Molecular Biology Developmental Biology Nerve Regeneration Skin-derived Precursors Schwann Cells Peripheral Nerve Injury Cell Transplantation Nsfc Grant Neural Regeneration Neural Regeneration Research, Volume 9, Issue 18
Content Type	Text
Resource Type	Article
Subject	Developmental Neuroscience

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