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Hyperproteic hypocaloric enteral nutrition in the critically ill patient: A randomized controlled clinical trial
| Content Provider | Scilit |
|---|---|
| Author | Rugeles, Saul Rueda, Juan-David Rosselli, Diego Diaz-Castrillon, Carlos |
| Copyright Year | 2013 |
| Abstract | Introduction: Our aim was to evaluate the impact of hyperproteic hypocaloric enteral feeding on clinical outcomes in critically ill patients, particularly on severity of organic failure measured with the Sequential Organ Failure Assessment (SOFA). Materials and Methods: In a double blind clinical trial, 80 critically ill adult patients were randomized to hyperproteic hypocaloric or to isocaloric enteral nutrition; all patients completed follow-up of at least 4 days. Prescribed caloric intake was: Hyperproteic hypocaloric enteral nutrition (15 kcal/kg with 1.7 g/kg of protein) or isocaloric enteral nutrition (25 kcal/kg with 20% of the calories as protein). The main outcome was the differences in delta SOFA at 48 h. Secondary outcomes were intensive care unit (ICU) length of stay, days on ventilator, hyperglycemic events, and insulin requirements. Results: There were no differences in SOFA score at baseline (7.5 (standard deviation (SD) 2.9) vs 6.7 (SD 2.5) P = 0.17). The total amount of calories delivered was similarly low in both groups (12 kcal/kg in intervention group vs 14 kcal/kg in controls), but proteic delivery was significantly different (1.4 vs 0.76 g/kg, respectively P ≤ 0.0001). The intervention group showed an improvement in SOFA score at 48 h (delta SOFA 1.7 (SD 1.9) vs 0.7 (SD 2.8) P = 0.04) and less hyperglycemic episodes per day (1.0 (SD 1.3) vs 1.7 (SD 2.5) P = 0.017). Discussion: Enteral hyperproteic hypocaloric nutrition therapy could be associated with a decrease in multiple organ failure measured with SOFA score. We also found decreased hyperglycemia and a trend towards less mechanical ventilation days and ICU length of stay. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902568/pdf |
| Ending Page | 349 |
| Page Count | 7 |
| Starting Page | 343 |
| File Format | XHTML |
| ISSN | 09725229 |
| e-ISSN | 1998359X |
| DOI | 10.4103/0972-5229.123438 |
| Journal | Indian Journal of Critical Care Medicine |
| Issue Number | 6 |
| Volume Number | 17 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2013-12-01 |
| Access Restriction | Open |
| Subject Keyword | Pediatrics and Child Health Critical Care Hypocaloric Enteral Nutrition Permissive Underfeeding Randomized Controlled Trial Indian Journal of Critical Care Medicine, Volume 17, Issue 6 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
