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Hematological profile of newborns exposed to maternal human immunodeficiency virus and antiretroviral therapy
| Content Provider | Scilit |
|---|---|
| Author | Abdulqadir, Ibrahim Yusuf, Aminu Abba Ndakotsu, Muhammad Alhaji Isyaku, Mujtaba Mashi Tukur, Jamilu Musa, Abubakar Umar Ahmed, Sagir Gumel |
| Copyright Year | 2018 |
| Abstract | BACKGROUND: Thousands of pregnant women are infected with human immunodeficiency virus (HIV) and some of them take antiretroviral therapy (ART) either for their own health or as a means of preventing mother-to-child transmission. This entails fetal exposure to drugs with attendant effect on hematological parameters. AIMS: The aim of this study is to determine the effect of maternal HIV and ART on hematological profile of newborns. SETTINGS AND DESIGN: Comparative cross-sectional study involving 70 each of HIV- and ART-exposed and HIV- and ART-unexposed newborns at Aminu Kano Teaching Hospital, Kano, Nigeria. SUBJECTS AND METHODS: Cord blood was collected for hemogram, reticulocyte count, and erythrocyte sedimentation rate. STATISTICAL ANALYSIS USED: Data were analyzed using SPSS version 20 and P < 0.05 was considered statistically significant. RESULTS: The mean hematocrit, platelet, and reticulocyte counts of the HIV-exposed newborns were significantly lower than those of HIV-unexposed (P < 0.05). Among HIV-exposed newborns, newborns of mothers with $CD4^{+}$ T-cell <350/μl had significantly lower hematological parameters than those of mothers with $CD4^{+}$ T-cell ≥350/μl (P < 0.05). Furthermore, HIV-exposed newborns of mothers on second-line ART had significantly lower hematological parameters than HIV-exposed newborns of mothers on the first-line ART (P < 0.05). There was positive correlation between maternal $CD4^{+}$ T-cell count and newborns' hematocrit (r = 0.71), platelet count (r = 0.54), and reticulocyte count (r = 0.63). CONCLUSIONS: Newborns exposed to maternal HIV and ART had lower hematological parameters than HIV-unexposed newborns and maternal $CD4^{+}$ T-cell count <350/μl and second-line ART were significantly associated with lower hematological parameters. |
| Related Links | https://www.jahjournal.org/article.asp?issn=1658-5127;year=2018;volume=9;issue=3;spage=95;epage=100;aulast=Abdulqadir;type=2 |
| File Format | XHTML |
| ISSN | 16585127 |
| DOI | 10.4103/joah.joah_57_17 |
| Journal | Journal of Applied Hematology |
| Issue Number | 3 |
| Volume Number | 9 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2018-01-01 |
| Access Restriction | Open |
| Subject Keyword | Pediatrics and Child Health Antiretroviral Therapy Cord Blood Exposed Newborns Hematological Profile Human Immunodeficiency Virus Journal of Applied Hematology, Volume 9, Issue 3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
