NDLI: Core needle biopsy versus fine needle aspiration cytology in bone and soft tissue tumors

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Core needle biopsy versus fine needle aspiration cytology in bone and soft tissue tumors

Content Provider	Scilit
Author	Rekhi, Bharat
Copyright Year	2019
Abstract	Fine needle aspiration cytology (FNAC) for diagnosis of musculoskeletal tumors is well discussed and debated. The current evidence restricts its application in recurrent and metastatic lesions, with core needle biopsy as the acceptable technique/gold standard for the primary diagnosis of these challenging tumors. However, there are several studies showing reasonable sensitivity and specificity in primary diagnosis of bone and soft tissue tumors, especially in differentiating benign from malignant tumors. There is an acceptable limitation in the exact subtyping of soft tissue tumors, based on cytology smear examination, in the absence of ancillary techniques. Nonetheless, cytology constitutes an optimal material for triaging cases for ancillary techniques, such as immunocytochemistry, immunohistochemistry, molecular cytogenetics, and molecular diagnosis, in the form of smears and cell block preparations. This review focuses on the strengths and limitations of cytology versus core needle biopsy in the diagnosis of bone and soft tissue tumors, with the current evidence in the form of published studies, including the authors' experience.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425772/pdf https://www.jcytol.org/article.asp?issn=0970-9371;year=2019;volume=36;issue=2;spage=118;epage=123;aulast=Rekhi;type=2
Ending Page	123
Page Count	6
Starting Page	118
File Format	XHTML
ISSN	09709371
e-ISSN	09745165
DOI	10.4103/joc.joc_125_18
Journal	Journal of Cytology
Issue Number	2
Volume Number	36
Language	English
Publisher	Medknow
Publisher Date	2019-01-01
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Fine Needle Aspiration Cytology of Bone and Soft Tissue Tumors Immunocytochemistry Immunohistochemistry of Sarcomas Journal of Cytology, Volume 36, Issue 2
Content Type	Text
Resource Type	Article
Subject	Histology Pathology and Forensic Medicine

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