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Estimation of Periostin and Tumour Necrosis Factor-α in Type II Diabetics with Chronic Periodontitis: A case–control study
| Content Provider | Scilit |
|---|---|
| Author | Prakash, Ponnudurai Samuel Gnana Radhika, Burra Naga Appukuttan, Deva Priya Subramanian, Sangeetha Victor, Dhayanand John Balasundaram, Aruna |
| Copyright Year | 2019 |
| Abstract | Background: Periostin, a matricellular protein, is downregulated in chronic inflammatory periodontal disease and is negatively modulated by tumor necrosis factor-α (TNF-α) in human periodontal fibroblast cell culture. The study aimed to estimate the gingival crevicular fluid (GCF) levels of periostin and TNF-α and to discern their relationship in chronic periodontitis (CP) individuals with and without Type II diabetes mellitus (DM). Materials and Methods: A total of 60 participants were divided into three groups, with 20 in each group. Group I – systemically and periodontally healthy, Group II – generalized CP, and Group III – generalized CP with Type II DM. Plaque index, gingival index, sulcular bleeding index, probing depth, and clinical attachment level were recorded. GCF periostin and TNF-α were quantified using the enzyme-linked immunosorbent assay. Results: Intergroup comparison was performed using the one-way ANOVA and Kruskal–Wallis. The relationship between the variables was analyzed using the Pearson's and Kendall's Tau correlation. The GCF periostin levels in Groups I, II, and III was 27.52 ± 2.39 ng/mL, 20.18 ± 1.42 ng/mL, and 16.77 ± 3.29 ng/mL, respectively. The GCF TNF-α levels in Groups I, II, and III was 92.41 ± 19.30 ng/L, 118.53 ± 21.93 ng/L, and 147.67 ± 16.35 ng/L, respectively. Periostin decreased, and TNF-α increased in periodontal disease; moreover, periostin level correlated negatively with all the site-specific clinical parameters whereas TNF-α positively correlated (P < 0.001). Conclusions: TNF-α strongly and negatively downregulates periostin in a chronically inflamed locale leading to compromised integrity of the periodontium. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434735/pdf https://www.jisponline.com/article.asp?issn=0972-124X;year=2019;volume=23;issue=2;spage=106;epage=112;aulast=Radhika;type=2 |
| Ending Page | 112 |
| Page Count | 7 |
| Starting Page | 106 |
| File Format | XHTML |
| ISSN | 0972124X |
| e-ISSN | 09751580 |
| DOI | 10.4103/jisp.jisp_397_18 |
| Journal | Journal of Indian Society of Periodontology |
| Issue Number | 2 |
| Volume Number | 23 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Dentistry and Oral Surgery Chronic Periodontal Disease Gingival Crevicular Fluid Periostin Tumor Necrosis Factor-alpha Type Ii Diabetes Mellitus Journal of Indian Society of Periodontology, Volume 23, Issue 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Periodontics |
