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Caldesmon Expression in Metastatic and Non-Metastatic Oral Squamous Cell Carcinoma—A Mediator of Epithelial Mesenchymal Transition
| Content Provider | Scilit |
|---|---|
| Author | Sekar, B. Saranyan, R. Murugesan, Ambika Kamaraj, L. Nirmal, R. Madhavan Kumaresan, Indrapriyadharshini |
| Copyright Year | 2019 |
| Abstract | Introduction: For the past decades long-term survival of oral squamous cell carcinoma (OSCC) patients remain unchanged which provides a wide platform for research. Caldesmon (CaD), an actin-myosin binding protein, has a contributing role in cytoskeleton modulation and cell motility. The aim of this study is to evaluate the expression of CaD in metastatic and non-metastatic OSCC and to discuss the possible role of CaD in epithelial mesenchymal transition. Materials and Methods: Archival blocks of 25 metastatic and 25 non-metastatic OSCC patients are included where CaD expression is evaluated immunohistochemically. Results: Overall expression and staining intensity of CaD were statistically significant in different grades of metastatic and non-metastatic OSCC. In summary, high expression of CaD is observed in increasing grades of OSCC but the metastatic potential of the tumour doesn’t seem to have any relation with CaD. |
| Related Links | https://www.jofs.in/article.asp?issn=0975-8844;year=2019;volume=11;issue=2;spage=105;epage=109;aulast=Sekar;type=2 |
| File Format | XHTML |
| ISSN | 09758844 |
| DOI | 10.4103/jofs.jofs_140_19 |
| Journal | Journal of Orofacial Sciences |
| Issue Number | 2 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Dentistry and Oral Surgery Caldesmon Epithelial Mesenchymal Transition Metastatic Non-metastatic Oral Squamous Cell Carcinoma Journal of Orofacial Sciences, Volume 11, Issue 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oral Surgery Orthodontics |
