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Neuropharmacological effects of methanolic extract of Clerodendrum viscosum leaves on wistar albino rats
| Content Provider | Scilit |
|---|---|
| Author | Bhattacharya, Ayon Santra, Soumya Ghosh, Goutam Nanda, Bijaya B. Rath, Meera Rath, Karmajeet |
| Copyright Year | 2018 |
| Abstract | Background: The aim is to study the central nervous system (CNS) depressant, anxiolytic, and antiepileptic activities of methanolic extract of Clerodendrum viscosum (MECV) leaves. Materials and Methods: The study comprised five groups each with 6 Wistar albino rats. The Group 1 or the positive control (phenytoin 30 mg/kg for the epilepsy model, and diazepam 1 mg/kg for the other models), Group 2 or negative control (0.9% NaCl at 10 ml/kg), and Groups 3–5 or the test drug group (MECV at 200, 400, and 800 mg/kg). Actophotometer test, staircase test, maximal electroshock seizure (MES) test, and the thiopentone sodium-induced sleep test, were used to study the various parameters. Results: The actophotometer test, MES, and staircase test (steps climbed) were analyzed using parametric tests. The sleep induction and staircase test (number of rears) were evaluated using nonparametric tests. A dose-dependent significant (P < 0.05) response was observed in the actophotometer test, sleep induction, and MES tests in comparison to control. In the staircase test at 200 and 400 mg/kg, increase in the number of steps climbed, and at 800 mg/kg decrease in both the number of steps climbed and rears were observed in comparison to control. Conclusion: MECV showed a dose-dependent CNS depressant action in the sleep induction and antiepileptic tests. A CNS stimulant action was observed at low dose (200 mg/kg) and depressant action at a higher dose (800 mg/kg) in the staircase test in comparison to control. Abbreviations used: GLP: Good laboratory practice; CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals; IAEC: Institutional Animal Ethical Committee; CNS: Central nervous system; BZDs: Benzodiazepines; IP: Intraperitoneal ANOVA: Analysis of variance; MECV: Clerodendrum viscosum; HLE: Hind limb extension; HLF: Hind limb flexion; NMDA: N-methyl-D-aspartate; MES: Maximal electroshock seizures; MECV: Methanolic extract of Clerodendrum viscosum; GABA: Gamma-Aminobutyric acid; CCK: Cholecystokinin; PME: Pseudospondias microcarpa; ECG: Electrocardiography; REM: Rapid eye movement; NREM: Nonrapid eye movement. |
| Related Links | http://www.phcog.com/article.asp?issn=0973-1296;year=2018;volume=14;issue=59;spage=507;epage=514;aulast=Rath;type=2 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/pm.pm_267_18 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 59 |
| Volume Number | 14 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2018-01-01 |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Actophotometer Clerodendrum Viscosum Maximal Electroshock Seizure Sleep Pharmacognosy Magazine, Volume 14, Issue 59 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
