NDLI: A potential immunological diagnostic marker for acute myeloid leukemia: the expression of the immune checkpoint B and T lymphocyte attenuator

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A potential immunological diagnostic marker for acute myeloid leukemia: the expression of the immune checkpoint B and T lymphocyte attenuator

Content Provider	Scilit
Author	Elleboudy, Nooran S. Radwan, Sara M. Kamal, Amany M. Nabih, Nermeen A. El-Kholy, Amal A.
Copyright Year	2020
Abstract	Introduction Provided the physiologic tumor suppressive role a healthy immune system has, diagnosis of cancer is sometimes also regarded as a diagnosis of an immune dysfunction. Immunoediting refers to the change of immune system response from tumor protection to tumor promotion, favoring the growth of poorly immunogenic clones that have the ability to evade the immune response. Among the mechanisms by which the tumor cells bypass the immune system is immune checkpoints. Which are immune inhibitory pathways responsible for self-tolerance and limiting self-tissue damage by controlling the magnitude and duration of the immune reaction. Objective Studying the expression of the novel immune checkpoint BTLA in patients with AML and evaluate its clinicopathological and diagnostic significance. Patients and methods We investigated the expression of BTLA gene in 60 AML cases and 15 healthy controls using RT-PCR. Results The current study revealed that significant up regulation of BTLA mRNA expression in AML patients as in comparison with the control group (P=0.024). Discussion These results provide a basis for the perception that BTLA upregulation is involved in inhibition of antitumor immunity and that high BTLA expression level can be made use of as a diagnostic marker in patients with AML.
Related Links	http://www.ehj.eg.net/article.asp?issn=1110-1067;year=2020;volume=45;issue=2;spage=92;epage=96;aulast=Radwan;type=2
File Format	XHTML
ISSN	11101067
DOI	10.4103/ejh.ejh_13_20
Journal	The Egyptian Journal of Haematology
Issue Number	2
Volume Number	45
Language	English
Publisher	Medknow
Publisher Date	2020-01-01
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Rheumatology Acute Myeloid Leukemia B and T Lymphocyte Attenuator Cancer Immunology Immune Checkpoints T Cells The Egyptian Journal of Haematology, Volume 45, Issue 2
Content Type	Text
Resource Type	Article

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