NDLI: The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes

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The role of matrix metalloproteinases 2 in atherosclerosis of patients with chronic kidney disease in type 2 diabetes

Content Provider	Scilit
Author	Sadek, Khaled M. Soliman, Amin R. Thabet, Karem K. Ahmed, Dina H. Mohamed, Osama M.
Copyright Year	2019
Abstract	Matrix metalloproteinase-2 (MMP2) has been implicated in chronic disease and cardiovascular disease. However, there is no knowledge about the correlations between serum levels of MMP-2, proteinuria and atherosclerosis in patients with diabetic nephropathy (DN). We investigated whether serum MMP-2 levels were associated with proteinuria, intima-media thickness (IMT) in DN patients. Diabetic patients not on hemodialysis (n = 50) were enrolled for the study. MMP-2 levels were measured using an ELISA system. IMT was evaluated by highresolution ultrasonography. Univariate analyses revealed that MMP-2 (P = 0.013) were independent correlates of proteinuria. Further, multivariate analyses revealed that MMP-2 levels (P = 0.001) were independent correlates of IMT. MMP-2 levels were significantly (P = 0.001) higher in patients with atherosclerosis than those without it. The present study demonstrates that serum levels of MMP-2 were one of the independent correlates of proteinuria and IMT in patients with DN. Our results suggest that serum MMP-2 levels may be one of the risk factors for renal damage and atherosclerosis in DN patients.
Related Links	http://www.sjkdt.org/article.asp?issn=1319-2442;year=2019;volume=30;issue=2;spage=387;epage=393;aulast=Soliman;type=2
Ending Page	393
Page Count	7
Starting Page	387
File Format	XHTML
ISSN	13192442
DOI	10.4103/1319-2442.256846
Journal	Saudi Journal of Kidney Diseases and Transplantation
Issue Number	2
Volume Number	30
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Medical Laboratory Technology Diabetic Nephropathy Chronic Kidney Disease Proteinuria Matrix Metalloproteinase Atherosclerosis in Patients Saudi Journal of Kidney Diseases and Transplantation, Volume 30, Issue 2
Content Type	Text
Resource Type	Article
Subject	Transplantation Nephrology

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