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Pathology and immunohistochemistry of capsular bag in spontaneously late dislocated capsular bag-intraocular lens complex
| Content Provider | Scilit |
|---|---|
| Author | Bhattacharjee, Harsha Bhattacharjee, Kasturi Das, Dipankar Singh, Manpreet Sukumar, Piruthivi Misra, Diva Kant |
| Copyright Year | 2017 |
| Abstract | Purpose: Our study aims to evaluate the morphology, histopathology, and immunohistochemistry of the spontaneously late dislocated capsular bag-intraocular lens (CB-IOL) complex. Various etiologies and possible pathogenesis of the event are also discussed. Methods: This was a tertiary-care setting and retrospective observational case series. The surgically explanted intact specimens of spontaneously late dislocated CB-IOL complex were studied. The demographics, duration of pseudophakia, IOL design/material, and specimen measurements were noted. Fresh specimens were photographed, and computer software was used for measurements. After processing, a detailed microscopic examination was carried out for three different sections of each specimen with hematoxylin and eosin (H and E), Masson's-trichrome, and immunohistochemistry stain for vimentin. The Mann–Whitney U-test was used for the statistical analysis. Results: Of 12 specimens, the mean CB and capsulorhexis opening size were 8.32 ± 0.8 mm and 3.62 ± 0.61 mm, respectively. The average CB-IOL complex size of our study was significantly lower than the studies reported in the literature (P ≤ 0.001). All (n = 12, 100%) were acrylic IOLs with 11 (91.67%) having single-piece design. All specimens on H and E stain showed extensive subepithelial fibrosis while Masson's trichrome staining showed that none had any pseudoexfoliation material. The circumferential sphincter-like fibrous tissue arrangement was seen in all specimens. Immunohistochemical expression of vimentin suggested the mesenchymal metaplasia of epithelial A-cells. Conclusion: Significant fibrotic contraction of the CB and phimosis of capsulorhexis may cause a progressive zonular tear. This is probably the most important etiology of spontaneous late dislocation of the CB-IOL complex. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678330/pdf http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=10;spage=949;epage=954;aulast=Bhattacharjee;type=2 |
| Ending Page | 954 |
| Page Count | 6 |
| Starting Page | 949 |
| File Format | XHTML |
| ISSN | 03014738 |
| e-ISSN | 19983689 |
| DOI | 10.4103/ijo.ijo_790_16 |
| Journal | Indian Journal of Ophthalmology |
| Issue Number | 10 |
| Volume Number | 65 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Ophthalmology Late Capsular Bag-intraocular Lens Complex Dislocation Lens Capsule Contraction Lens Capsule Immunohistochemistry Pseudoexfoliation Syndrome Indian Journal of Ophthalmology, Volume 65, Issue 10 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
