Loading...
Please wait, while we are loading the content...
Similar Documents
Immunohistochemical analysis of osteopontin expression in oral squamous cell carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Jeyasivanesan, Dhana Lakshmi Pandiar, Deepak Basheer, Shaini Mohamed, Shameena Pazhaningal |
| Copyright Year | 2019 |
| Abstract | Background: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Osteopontin (OPN) has been proved as a biomarker in varying malignant tumors. Only limited studies detail the role of OPN in OSCC. Aims: This study aims to demonstrate the expression of OPN in OSCC and to correlate the expression of OPN with the histologic grades of OSCC. Settings and Design: This is a retrospective immunohistochemical study in Dravidian population (linguistically Malayalam). Materials and Methods: Thirty diagnosed cases of OSCC were subjected to immunohistochemistry using OPN antibody for detection of OPN expression. Ten normal oral mucosal specimens were also stained as controls. Statistical Analysis Used: Chi-square test and ANOVA followed by Bonferroni test. Results: OPN expression was significantly higher in OSCC patients than in controls. In normal oral mucosal specimens, none of them showed OPN immunoreactivity. A significant difference was observed between total scores and intensities of normal and varying grades of OSCC. A significant difference was also observed between the percentage of positive cells for OPN expression of normal and varying grades of OSCC. However, no significant difference was observed between the percentage of positive cells for OPN expression of well-, moderate-, poorly-differentiated carcinomas. Correlation of OPN expression with lymph node status, site, and sex was found to be statistically insignificant. Conclusion: Insights gained from this study may lead to research targeted at the treatment of OSCC. |
| Related Links | http://www.ijdr.in/article.asp?issn=0970-9290;year=2019;volume=30;issue=4;spage=539;epage=543;aulast=Jeyasivanesan;type=2 |
| Ending Page | 543 |
| Page Count | 5 |
| Starting Page | 539 |
| File Format | XHTML |
| ISSN | 09709290 |
| e-ISSN | 19983603 |
| DOI | 10.4103/ijdr.ijdr_474_17 |
| Journal | Indian Journal of Dental Research |
| Issue Number | 4 |
| Volume Number | 30 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Dentistry and Oral Surgery Moderately Differentiated Squamous-cell Carcinoma Oral Squamous Cell Carcinoma Osteopontin Poorly Differentiated Squamous-cell Carcinoma Well-differentiated Squamous Cell Carcinoma Indian Journal of Dental Research, Volume 30, Issue 4 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dentistry Medicine |
