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Lornoxicam versus tramadol for post-operative pain relief in patients undergoing ENT procedures
| Content Provider | Scilit |
|---|---|
| Author | Harethy, Sami Al Abdelhalim, Ashraf A. Moustafa, Mohamed |
| Copyright Year | 2014 |
| Abstract | Background: Pain following ear-nose and throat surgery is one of the most important complaints for which, several drugs are used. This prospective, randomized, double-blind controlled trial was designed to compare the analgesic effect of tramadol versus lornoxicam for post-operative pain relief in patients undergoing ENT surgical procedures. Methods: One hundred and twenty patients of ASA class I-II, who had undergone elective ENT surgical procedures under general anesthesia, were assigned in a randomized manner into three equal groups. Group L received lornoxicam8 mg IV, Group T received tramadol 1 mg/kg IV and Group C received IV saline after induction of anesthesia before the start of the surgery. Post-operative pain was assessed using the visual analogue scale (VAS) and sedation level was evaluated during stay in the post-anesthesia care unit with a four-point sedation scale. Intraoperative blood loss was estimated using the Five-Point Scale. Adverse events in the first 24 h post-operative were recorded. Results: The VAS pain scores were significantly higher in Group C as compared with those in Groups L and T at 30 min and 1, 2, 4and 6 h post-operatively, with no significant difference between Group L and Group T. The amount of morphine consumption post-operatively was significantly lower in Group L (5.2 ± 2.5 mg) and Group T (5.0 ± 2.0 mg) as compared with that in Group C (7.4 ± 2.3 mg) (P = 0.001). The time for the first analgesic requirement was significantly less in Group L (92.62 ± 24.23 min) and Group T (88 ± 21.43 min) as compared with that in Group C (42.82 ± 25.61 min), with no significant difference between the other two groups. Estimated intraoperative blood loss score by the surgeons showed no significant difference between the three groups. The most frequent side-effects in the three groups were nausea and vomiting, and their incidence was significantly higher in the placebo group as compared with the other two groups. Conclusion: Tramadol 1 mg/kg was comparable to lornoxicam 8 mg for post-operative pain relief in patients undergoing ENT surgical procedures; both drugs helped to reduce the post-operative opioid requirement and consequently minimized the related adverse effects of the opioids. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950450/pdf http://www.saudija.org/article.asp?issn=1658-354X;year=2014;volume=8;issue=1;spage=38;epage=44;aulast=Abdelhalim;type=2 |
| Ending Page | 44 |
| Page Count | 7 |
| Starting Page | 38 |
| File Format | XHTML |
| ISSN | 1658354X |
| e-ISSN | 09753125 |
| DOI | 10.4103/1658-354x.125935 |
| Journal | Saudi Journal of Anaesthesia |
| Issue Number | 1 |
| Volume Number | 8 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2014-01-01 |
| Access Restriction | Open |
| Subject Keyword | Anesthesiology Ent Procedures Lornoxicam Post-operative Pain Relief Tramadol Saudi Journal of Anaesthesia, Volume 8, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
