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Prostate-specific antigen density as a parameter for the prediction of positive lymph nodes at radical prostatectomy

Content Provider	Scilit
Author	Rausch, Steffen Yiakoumos, Theocharis Kalble, Tilman
Copyright Year	2015
Abstract	Objective: The aim was to determine the prognostic ability of Partin's tables for a patient collective undergoing radical prostatectomy (RP) and to evaluate the association of prostate-specific antigen (PSA) density (PSAD) and postoperative lymph node status. Methods: From 1999 to 2006, 393 consecutive patients underwent RP at our Urology department. Patients with Gleason scores Results: Lymph node invasion (LNI) was found in 36 patients (9.16%). Kendall's rank correlation analysis revealed a significant association between the number of removed LN and LNI (P = 0.016). Patients with LNI had a significantly higher preoperative PSA and PSAD. Preoperative Gleason score was a significant predictor of LNI. The Partin tables' prediction of organ confined stages, extraprostatic extension, and seminal vesicle invasion was in line with the pathological findings in our collective. PSAD was a significant predictor of LNI in univariate and multivariate analysis. Conclusion: The most widely used nomogram is of high value in therapy decision-making, although it remains an auxiliary means. Considering the performance of lymph node dissection, surgeons should be aware of the specifics of the applied nomogram. PSAD appears as a useful adjunctive parameter for preoperative prostate risk estimation and warrants further evaluation.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660691/pdf
File Format	XHTML
ISSN	09747796
e-ISSN	09747834
DOI	10.4103/0974-7796.152118
Journal	Urology Annals
Issue Number	4
Volume Number	7
Language	English
Publisher	Medknow
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Andrology Lymph Node Invasion Nomogram Prostate Cancer Prostate-specific Antigen Density Radical Prostatectomy Urology Annals, Volume 7, Issue 4
Content Type	Text
Resource Type	Article
Subject	Urology

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