NDLI: Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves

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Anti-dopaminergic effect of the methanolic extract of Morus alba L. leaves

Content Provider	Scilit
Author	Nade, VandanaS Yadav, AdhikraoV
Copyright Year	2008
Abstract	To evaluate the effect of methanolic extract of Morus alba L. leaves on dopaminergic function. The effect of the methanolic extract of Morus alba L. leaves was evaluated on haloperidol and metoclopramide induced catalepsy, foot shock-induced aggression, amphetamine-induced stereotyped behavior and phenobarbitone induced sleeping in mice. In each of these tests, the extract was administered in doses of 50, 100 and 200 mg/kg, i.p., 30 min before performing the test in mice. Further, the inhibitory effect of the extract on dopamine was studied using isolated rat vas deferens. The extract produced significant dose dependent potentiation of haloperidol (1 mg/kg, i.p.) and metoclopramide (20 mg/kg, i.p.) induced catalepsy in mice. The extract significantly reduced number of fights and increased latency to fights in foot shock-induced aggression; it also decreased amphetamine (1 mg/kg, i.p.) induced stereotyped behavior in a dose dependent manner. The sleeping time induced by phenobarbitone (50 mg/kg, i.p.) too was prolonged. The extract inhibited contractions produced by dopamine on isolated rat vas deferens. The results suggest that the methanolic extract of Morus alba L. possesses antidopaminergic activity. Further neurochemical investigation can explore the mechanism of action of the plant drug with respect to antidopaminergic functions and help to establish the plant as an antipsychotic agent.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792621/pdf
Ending Page	226
Page Count	6
Starting Page	221
File Format	XHTML
ISSN	02537613
e-ISSN	19983751
DOI	10.4103/0253-7613.44154
Journal	Indian Journal of Pharmacology
Issue Number	5
Volume Number	40
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Anti-dopaminergic Catalepsy Morus Alba L Stereotypy Vas Deferens Indian Journal of Pharmacology, Volume 40, Issue 5
Content Type	Text
Resource Type	Article
Subject	Pharmacology Pharmacology (medical)

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