NDLI: Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

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Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

Content Provider	Scilit
Author	Dajem, Saad Bin Ali, Sara Bayoumi Salahaldin, Nouraldin Mahmoud Morsy, Kareem Fahmy, Sohair Ramadan Mohamed, Ayman Saber Abdelrady, Omar Ghanem Soliman, Ahmed Muhammed Kamal, Yasmin Mohamed Abdelazim, Ammar Yasser Mohamed, Aya Fadi
Copyright Year	2020
Abstract	Objective: To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in rats. Methods: The animals were divided randomly into three groups (n = 6 per group): control, gentamicin, and Allolobophora caliginosa coelomic fluid-treated groups. Toxicity was established after injection of gentamicin daily for 8 days at a dose of 100 mg/kg. Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total proteins, albumin, creatinine, urea, uric acid, malondialdehyde, glutathione, catalase and histopathology of tissues were investigated in the study. Results: Allolobophora caliginosa coelomic fluid significantly decreased urea, creatinine, uric acid, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde levels while significantly increasing levels of total proteins, albumin, glutathione and catalase. The histopathological investigation showed partial restoration of renal and hepatic architecture. Conclusions: This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.
Related Links	https://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=9;spage=411;epage=416;aulast=Dajem;type=2
File Format	XHTML
ISSN	22211691
DOI	10.4103/2221-1691.290132
Journal	Asian Pacific Journal of Tropical Biomedicine
Issue Number	9
Volume Number	10
Language	English
Publisher	Medknow
Publisher Date	2020-01-01
Access Restriction	Open
Subject Keyword	Gastroenterology and Hepatology Integrative and Complementary Medicine Allolobophora Caliginosa Coelomic Fluid Gentamicin Hepatorenal Toxicity Earthworm Asian Pacific Journal of Tropical Biomedicine, Volume 10, Issue 9
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology

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