Toxicological and biochemical studies on Schinus terebinthifolius concerning its curative and hepatoprotective effects against carbon tetrachloride-induced liver injury

Content Provider	Scilit
Author	Khalil, Waleed F. Abdou, Rania H. Saleh, Sherif Y.
Copyright Year	2015
Abstract	Background: Recently, many efforts have been made to discover new products of natural origin which can limit the xenobiotic-induced hepatic injury. Carbon tetrachloride (CCl$ _{4}$ ) is a highly toxic chemical that is widely used to study hepatotoxicity in animal models. Objective: The present study was conducted to investigate the curative and protective effects of Schinus terbenthifolius ethanolic extract against CCl$ _{4}$ -induced acute hepatotoxicity in rats. Materials and Methods: S. terbenthifolius extract was orally administered in a dose of 350 mg dried extract/kg b.wt. before and after intoxication with CCl$ _{4}$ for curative and protective experiments, respectively. A group of hepatotoxicity indicative enzymes, oxidant-antioxidant capacity, DNA oxidation, and apoptosis markers were measured. Results: CCl$ _{4}$ increased liver enzyme leakage, oxidative stress, hepatic apoptosis, DNA oxidation, and inflammatory markers. Administration of S. terebinthifolius, either before or after CCl$ _{4}$ intoxication, significantly decreased elevated serum liver enzymes and reinstated the antioxidant capacity. Interestingly, S. terebinthifolius extract inhibited hepatocyte apoptosis as revealed by approximately 20 times down-regulation in caspase-3 expression when compared to CCl$ _{4}$ untreated group. On the other hand, there was neither protective nor curative effect of S. terebinthifolius against DNA damage caused by CCl$ _{4}$ . Conclusion: The present study suggests that S. terebinthifolius extract could be a substantially promising hepatoprotective agent against CCl$ _{4}$ toxic effects and may be against other hepatotoxic chemical or drugs.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461974/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=42;spage=93;epage=101;aulast=Abdou;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/0973-1296.157705
Journal	Pharmacognosy Magazine
Issue Number	42
Volume Number	11
Language	English
Publisher	Medknow
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Toxicology Antioxidant Apoptosis Hepatoprotective Hepatotoxicity Schinus Terebinthifolius Pharmacognosy Magazine, Volume 11, Issue 42
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science