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Blocking leukotrienes optimize asthma control: The BLOC survey
| Content Provider | Scilit |
|---|---|
| Author | Idrees, Majdy M. Moamary, Mohamed S. Al |
| Copyright Year | 2007 |
| Abstract | Objective: The aim of this study was to evaluate asthma control after the introduction of a leukotriene modifier (Montelukast), in addition to the current controller asthma therapies, in patients with inadequately controlled mild-to-moderate persistent asthma. Asthma control and patient perception were assessed prior to, and 4 weeks after, the introduction of Montelukast, and the pre-introduction and post-introduction results were compared. Materials and Methods: A cross-sectional, observational study collected information on 1,490 eligible adult asthmatic patients in Saudi Arabia. The eligibility criteria included patients aged 15 years or more with symptomatic mild-to-moderate persistent asthma despite treatment with inhaled corticosteroids with or without long-acting beta agonist; also, the patient should attend the initial visit and follow-up visits after at least 4 weeks. Results: Of the 1,490 eligible patients, 79.5% received inhaled corticosteroids alone, and the remaining 20.5% received combination of inhaled corticosteroids and long-acting bronchodilator. Despite the treatment with daily controller medications, asthma symptoms persisted in more than two-thirds of the study population. Upon adding Montelukast, more than 80% of patients reported improvement in symptoms, which was consistent in all patients irrespective of corticosteroid type or dose (stratum) or the addition of long-acting β2-agonist. At the follow-up visit, 92.2% of patients reported that they felt better on Montelukast. Conclusion: $Leukotriene^{ }$ modifier Montelukast has significant additive benefits in the management of patients who suffer from mild-to-moderate asthma and who are inadequately controlled on inhaled corticosteroids therapy with or without long-acting bronchodilator. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732093/pdf |
| File Format | XHTML |
| ISSN | 18171737 |
| e-ISSN | 19983557 |
| DOI | 10.4103/1817-1737.33696 |
| Journal | Annals of Thoracic Medicine |
| Issue Number | 3 |
| Volume Number | 2 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Allergy Asthma Inflammation Annals of Thoracic Medicine, Volume 2, Issue 3 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine |
