NDLI: Discordant Primary Resistance to Imatinib Mesylate in the Same Individual and Splenic Involvement in Recurring Gastric Gastrointestinal Stromal Tumors: Assessment by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

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Discordant Primary Resistance to Imatinib Mesylate in the Same Individual and Splenic Involvement in Recurring Gastric Gastrointestinal Stromal Tumors: Assessment by Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography

Content Provider	Scilit
Author	Basu, Sandip Fargose, Preeti
Copyright Year	2018
Abstract	Discordant primary resistance and response of the metastatic lesions in the same individual coupled with splenic involvement in gastrointestinal stromal tumors (GISTs) are relatively uncommon. We herein report such a case of recurring GIST of the stomach that presented with the involvement of spleen with$ ^{18}$F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) imaging documentation. Ultrasonography-guided fine needle aspiration cytology from the splenic and paravesical lesions demonstrated metastatic spindle cell tumor consistent with diagnosis of metastasis from GIST of the stomach. The splenic and the paravesical lesions appeared resistant to the conventional 400 mg of imatinib mesylate, while most other abdominopelvic metastatic lesions demonstrated good metabolic response on FDG-PET/CT, with the noteworthy findings of interlesional heterogeneity of the metastatic lesions in terms of differential primary response in the same individual.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5883433/pdf http://www.ijnm.in/article.asp?issn=0972-3919;year=2018;volume=33;issue=2;spage=140;epage=142;aulast=Fargose;type=2
File Format	XHTML
ISSN	09723919
e-ISSN	09740244
DOI	10.4103/ijnm.ijnm_142_17
Journal	Indian Journal of Nuclear Medicine
Issue Number	2
Volume Number	33
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Cell Tissue Engineering Pathology 18f-fluorodeoxyglucose-positron Emission Tomography/computed Tomography Gastrointestinal Stromal Tumors Imatinib Mesylate Splenic Metastasis Indian Journal of Nuclear Medicine, Volume 33, Issue 2
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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