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Modulatory Role of Shorea robusta Bark on Glucose-metabolizing Enzymes in Diethylnitrosamine Induced Hepatocellular Carcinoma in Rats
| Content Provider | Scilit |
|---|---|
| Author | Kalaiselvan, A. Anand, T. Gokulakrishnan, K. Velavan, S. Kamaraj, Mc |
| Copyright Year | 2015 |
| Abstract | Introduction: The modulations of glucose-metabolizing enzyme activities play a vital rolein the depletion of energy metabolism and leads to inhibition of cancer growth. Objective: To find the effect of shorearobusta bark extract on glucose-metbolizing enzymes in diethylnitrosamine (DEN) induced hepatocellular carcinoma rats. Materials and Methods: Biochemical evaluation of glucose metabolizing enzyme were done in before and after shorearobusta bark extract (500mg/kg) treatment in DEN induced rats. Results: A significant increasein the activities of the key glycolytic enzymes viz., hexokinase and phosphoglucoisomerase, with a significant decrease in the gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatasewere observed in HCC bearing rats, when compared with the control. Administration of shorearobusta extract caused a significant decrease in theactivities of glycolytic enzymes and an increase in the gluconeogenic enzymes activities to near normal values. Conclusion: The current findings suggest that the S. robusta extract has a definite modulating role on the key enzymes ofglucose-metabolism in HCC. The modulatory effect may be due to the phytoactive constituents present in the extract of S. robusta. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745223/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=44;spage=496;epage=500;aulast=Kalaiselvan;type=2 |
| Ending Page | S500 |
| Page Count | 5 |
| Starting Page | S496 |
| File Format | XHTML |
| ISSN | 09731296 |
| e-ISSN | 09764062 |
| DOI | 10.4103/0973-1296.168981 |
| Journal | Pharmacognosy Magazine |
| Issue Number | 44 |
| Volume Number | 11 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Integrative and Complementary Medicine Diethylnitrosamine Glucose-metabolizing Enzymes Hepatocellular Carcinoma Shorea Robusta Pharmacognosy Magazine, Volume 11, Issue 44 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmaceutical Science |
