Bioactivities of ethanolic extract and its fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) species

Content Provider	Scilit
Author	Ustun, Osman Baykal, Turhan Ozcelik, Berrin-
Copyright Year	2016
Abstract	Background: Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) have been used for treatment of some illnesses in Turkish folk medicine. In the present study, the ethanolic extract and its fractions obtained using re-extraction by hexane (Hx), chloroform $(CHCl_{3}$), butanol, and remaining-water $(r-H_{2}$O) of C. laurifolius were screened for their in vitro bioactivities. Materials and Methods: Activities were determined against both standard and the isolated strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus, Enterococcus faecalis, as well as yeasts such as Candida albicans and Candida parapsilosis by microdilution method. Also, antiviral activity of C. laurifolius and S. wiedemannii extracts were tested on herpes simplex virus-1 (HSV-1) and parainfluenza-3 (PI-3) using Madin-Darby bovine kidney and vero cell lines. Results: Tested extracts of C. laurifolius (minimum inhibitory concentration 32 μg/mL) exerted a strong antimicrobial activity against Gram-negative bacteria of E. coli, P. mirabilis, K. pneumoniae, and A. baumannii. Conclusion: The Hx extract of C. laurifolius (cytopathogenic effect of 32–8 μg/mL) had antiviral activity on PI-3. Also, the $r-H_{2}$O, $CHCl_{3}$, and ethanol extracts (16–<0.25 μg/mL) of S. wiedemannii had significant antiviral activity on HSV-1, same as control.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792006/pdf http://www.phcog.com/article.asp?issn=0973-1296;year=2016;volume=12;issue=45;spage=82;epage=85;aulast=Ustun;type=2
File Format	XHTML
ISSN	09731296
e-ISSN	09764062
DOI	10.4103/0973-1296.176125
Journal	Pharmacognosy Magazine
Issue Number	45
Volume Number	12
Language	English
Publisher	Medknow
Publisher Date	2016-01-01
Access Restriction	Open
Subject Keyword	Integrative and Complementary Medicine Antibacterial Activity Antifungal Activity Antiviral Activity Cistus Laurifolius Cytotoxicity Salvia Wiedemannii Pharmacognosy Magazine, Volume 12, Issue 45
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmaceutical Science