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CD14 as a potential prognostic factor and Bcl-2 as a therapeutic target in egyptian B-Cell chronic lymphocytic leukemia patients
| Content Provider | Scilit |
|---|---|
| Author | Hussin, Ola Ali Zaewer, Mohga Mahmoud Khalifa, Naglaa Ali Morsy, Mohamed Hanfy Elnaggar, Amina Mohamed El-Khawanky, Mohamed Mahmoud |
| Copyright Year | 2019 |
| Abstract | INTRODUCTION: B-cell chronic lymphocytic leukemia (B-CLL) is a unique lymphoproliferative disorder that scarcely occurs under the age of 40. B-CLL represents a neoplastic disorder caused primarily by defective programmed cell death and accompanied by a myriad of cellular and humoral immune defects. AIM: This study aimed to assess Bcl-2 and CD14 expression in B-CLL patients and their study as probable prognostic and therapy targeting factors. PATIENTS AND METHODS: In this study, we assessed Bcl-2 and cluster of differentiation (CD14) expression in a group of Egyptian patients with B-CLL. Forty B-CLL patients and 20 apparently healthy individuals served as the control group were included in this study. STATISTICAL ANALYSIS: SPSS statistical software (IBM SPSS Inc., version 20, Chicago, Illinois, USA) was used for statistical analysis. RESULTS: Aberrant expression of Bcl-2 protein appeared in all B-CLL patients (100%). Bcl-2 expression showed a highly positive correlation with total lymphocyte count and lymphocyte count (P =0.000 for both) and a positive correlation with lactate dehydrogenase (P = 0.044). The expression of myelomonocytic antigen “CD14” above the cutoff value 5 × 109/L was reported in 70% (28/40) of B-CLL patients, 55.6% (10/18) of the intermediate-risk group, and 81.8% (18/22) of high-risk group. CONCLUSION: There was a significant increase in Bcl-2 protein and CD14 in B-CLL patients. Bcl-2 was highly increased in all patients and CD14 more observed in the high-risk group than that of the intermediate risk group. |
| Related Links | https://www.jahjournal.org/article.asp?issn=1658-5127;year=2019;volume=10;issue=1;spage=23;epage=28;aulast=El-Khawanky;type=2 |
| File Format | XHTML |
| ISSN | 16585127 |
| DOI | 10.4103/joah.joah_5_19 |
| Journal | Journal of Applied Hematology |
| Issue Number | 1 |
| Volume Number | 10 |
| Language | English |
| Publisher | Medknow |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Medical Laboratory Technology Apoptosis B-cell Chronic Lymphocytic Leukemia Bcl-2 Flow Cytometry Immunophenotyping Journal of Applied Hematology, Volume 10, Issue 1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology |
