NDLI: Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level: what to expect in the Chinese population?

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Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level: what to expect in the Chinese population?

Content Provider	Scilit
Author	Ho, BrianSH Teoh, JeremyYC Yuen, SteffiKK Wong, CharlesKW Ng, AdaTL Ma, Wai-Kit Ho, Kwan-Lun Yiu, Ming-Kwong Tsu, JamesHL
Copyright Year	2014
Abstract	We investigated the prostate cancer detection rates upon transrectal ultrasound (TRUS)-guided biopsy in relation to digital rectal examination (DRE) and prostate-specific antigen (PSA), and risk factors of prostate cancer detection in the Chinese population. Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database. The prostate cancer detection rates with reference to DRE finding and PSA level of < 4, 4-10, 10.1-20, 20.1-50 and > 50 ng ml-1 were investigated. Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection. A total of 2606 Chinese men were included. In patients with normal DRE, the cancer detection rates were 8.6%, 13.4%, 21.8%, 41.7% and 85.2% in patients with PSA < 4, 4-10, 10.1-20, 20.1-50 and > 50 ng ml-1 respectively. In patients with abnormal DRE, the cancer detection rates were 12.4%, 30.2%, 52.7%, 80.6% and 96.4% in patients with PSA < 4, 4-10, 10.1-20, 20.1-50 and > 50 ng ml-1 respectively. Older age, smaller prostate volume, larger number of biopsy cores, presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses (P < 0.001). Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population. Taking the different risk factors into account, an individualized approach to the decision of TRUS-guided biopsy can be adopted.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577598/pdf
File Format	XHTML
ISSN	1008682X
e-ISSN	17457262
DOI	10.4103/1008-682x.144945
Journal	Asian Journal of Andrology
Issue Number	5
Volume Number	17
Language	English
Publisher	Medknow
Publisher Date	2014-01-01
Access Restriction	Open
Subject Keyword	Andrology Reproductive Biology Asian Journal of Andrology, Volume 17, Issue 5
Content Type	Text
Resource Type	Article
Subject	Urology

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