NDLI: Brainstem dysfunction in patients with late-onset Lennox-Gastaut syndrome: Voxel-based morphometry and tract-based spatial statistics study

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Brainstem dysfunction in patients with late-onset Lennox-Gastaut syndrome: Voxel-based morphometry and tract-based spatial statistics study

Content Provider	Scilit
Author	Kim, Sung Eun Park, Kang Min Hur, Yun Jung
Copyright Year	2016
Abstract	There have been a few reports of patients who developed Lennox-Gastaut syndrome (LGS) in the second decades of their life. The aim of this study was to investigate electroclinical presentation in patients with late-onset LGS. In addition, we evaluated structural abnormalities of the brain, which may give some clue about the common pathogenic pathway in LGS. We enrolled the patients with late-onset LGS. We collected electroclinical characteristics of the patients and evaluated structural abnormalities using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analysis. The three subjects were diagnosed with late-onset LGS. The patients have no mental retardation and normal background activities on electroencephalography (EEG), and they had generalized paroxysmal fast activities on EEG, especially during sleep. The TBSS analysis revealed that fractional anisotropy values in the patients were significantly reduced in the white matter of brainstem compared with normal controls. However, VBM analysis did not show any significant difference between the patients and normal controls. Patients with late-onset LGS have different clinical and EEG characteristics from those with early-onset LGS. In addition, we demonstrated that brainstem dysfunction might contribute to the pathogenesis of late-onset LGS.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144479/pdf
Ending Page	522
Page Count	5
Starting Page	518
File Format	XHTML
ISSN	09722327
e-ISSN	19983549
DOI	10.4103/0972-2327.194462
Journal	Annals of Indian Academy of Neurology
Issue Number	4
Volume Number	19
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Neuroimaging Brain Stem Lennox-gastaut Syndrome Magnetic Resonance Imaging Annals of Indian Academy of Neurology, Volume 19, Issue 4
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical)

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