NDLI: Comparative efficacy of methylphenidate and atomoxetine in oppositional defiant disorder comorbid with attention deficit hyperactivity disorder

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Comparative efficacy of methylphenidate and atomoxetine in oppositional defiant disorder comorbid with attention deficit hyperactivity disorder

Content Provider	Scilit
Author	Garg, Jasmin Arun, Priti Chavan, Bs
Copyright Year	2015
Abstract	Background: Oppositional defiant disorder (ODD) is frequently comorbid with attention deficit hyperactivity disorder (ADHD) and is associated with substantial functional impairments. Methylphenidate and atomoxetine are well-established drugs for the management of ADHD. Some studies from Western countries have reported these drugs to be effective in the management of ODD comorbid with ADHD. This study aimed to assess if methylphenidate and atomoxetine are efficacious in treating Indian children with ODD comorbid with ADHD. Subjects and Methods: In this prospective, open-label study, 37 patients of age 6-14 years with a diagnosis of ODD comorbid with ADHD randomly received either methylphenidate (dose 0.2-1 mg/kg/day) or atomoxetine (dose 0.5-1.2 mg/kg/day) for 8 weeks. Improvements in ADHD and ODD symptoms were assessed using Vanderbilt ADHD diagnostic parent rating scale (VADPRS). Results: At 8 weeks, there were statistically significant improvements in both ADHD and ODD symptoms in both methylphenidate and atomoxetine groups, as per VADPRS. The improvements produced and tolerability was comparable in the two groups. 80% of the patients from methylphenidate group and 64.3% patients from atomoxetine group ceased to fulfill the criteria for the presence of ODD at 8 weeks. Conclusions: Methylphenidate and atomoxetine are effective in the treatment of ODD comorbid with ADHD in short duration.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456885/pdf
File Format	XHTML
ISSN	2229516X
DOI	10.4103/2229-516x.157162
Journal	International Journal of Applied and Basic Medical Research
Issue Number	2
Volume Number	5
Language	English
Publisher	Medknow
Publisher Date	2015-01-01
Access Restriction	Open
Subject Keyword	Psychiatry and Mental Health Atomoxetine Attention Deficit Hyperactivity Disorder Methylphenidate Oppositional Defiant Disorder International Journal of Applied and Basic Medical Research, Volume 5, Issue 2
Content Type	Text
Resource Type	Article

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