NDLI: Multiple myeloma presenting as gingival hyperplasia

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Multiple myeloma presenting as gingival hyperplasia

Content Provider	Scilit
Author	Kansal, Gaurav Gupta, Parul Jain, Sanjeev Kaur, Harjit
Copyright Year	2013
Abstract	Multiple myeloma is a malignant neoplasm that is characterized by a monoclonal proliferation of plasma cells. Oral and maxillofacial manifestations as an initial sign or symptom of multiple myeloma are rare. A 58-year-old male patient presented with generalized gingival enlargement for last 6 months. Based on clinical presentation, a diagnosis of gingival hyperplasia was made. After Phase I therapy, excisional biopsy was taken in anterior mandibular region and excised tissue was sent for histopathological examination. The histopathology report revealed a lining of stratified squamous epithelium with foci of ulceration. The subepithelial zone showed infiltration by sheets of mainly binucleate and multinucleate plasma cells, few cells being less differentiated. Rounded cytoplasmic inclusion bodies were identified in many of these cells. After a series of clinical investigations, a case of "multiple myeloma" was diagnosed. Patient presenting with generalized gingival hyperplasia should be worked up for systemic disease like multiple myeloma.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768194/pdf http://www.jisponline.com/article.asp?issn=0972-124X;year=2013;volume=17;issue=3;spage=391;epage=393;aulast=Jain;type=2
File Format	XHTML
ISSN	0972124X
e-ISSN	09751580
DOI	10.4103/0972-124x.115652
Journal	Journal of Indian Society of Periodontology
Issue Number	3
Volume Number	17
Language	English
Publisher	Medknow
Access Restriction	Open
Subject Keyword	Dentistry and Oral Surgery Gingival Enlargement Multiple Myeloma Plasma Cells Journal of Indian Society of Periodontology, Volume 17, Issue 3
Content Type	Text
Resource Type	Article
Subject	Periodontics

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