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Seasons can influence the results of the methacholine challenge test
| Content Provider | Scilit |
|---|---|
| Author | Sposato, Bruno Scalese, Marco Scala, Raffaele Naldi, Mario Pammolli, Andrea |
| Copyright Year | 2012 |
| Abstract | Objective: This study tried to evaluate whether a methacholine test may be influenced by the seasons. Methods: We considered 4826 consecutive subjects with normal spirometry (50.53% males; age: 35.1±16.2; forced expiratory volume in one second: 99.5±13.0%) who underwent a methacholine test for suspected asthma symptoms between 2000 and 2010. They were subdivided into four groups, like the seasons, according to the test dates. Results: A total of 1981 (41%) resulted normal (no PD$ _{20}$ was obtained with 2400 μg of methacholine); the others showed a mean LogPD$ _{20}$ of 2.52±0.5 μg. The number of subjects with bronchial hyper-responsiveness (BHR) found in autumn (789, 62.3%) was higher than in summer (583, 56.7%; P=0.03). A higher number of females and overweight/obese subjects showed a BHR in autumn compared with the other seasons. The spring mean LogPD$ _{20}$ value (2.48±0.48 μg) was lower if compared with the one measured in summer (2.59±0.49 μg; P=0.05). LogPD$ _{20}$ value was lower in females and non-smokers in spring compared with summer (P<0.05). Overweight/obese non-smokers showed a lower LogPD$ _{20}$ in spring and autumn compared with that in summer (P<0.05). Autumn was a risk factor (OR: 1.378; P=0.001) for BHR (using a PD$ _{20}$ <2 400 μg as BHR limit), while spring (OR: 1.330; P=0.021) and autumn (OR: 1.331; P=0.020) were risk factors for a more severe BHR (using a PD$ _{20}$ <400 μg as BHR limit). Conclusion: There was a higher probability of finding BHR in outpatients with suspected asthma in autumn and spring compared with summer. Spring is the season where BHR may be more severe. Females and overweight/obese subjects were those mainly involved in this seasonal variability of BHR. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339205/pdf |
| File Format | XHTML |
| ISSN | 18171737 |
| e-ISSN | 19983557 |
| DOI | 10.4103/1817-1737.94521 |
| Journal | Annals of Thoracic Medicine |
| Issue Number | 2 |
| Volume Number | 7 |
| Language | English |
| Publisher | Medknow |
| Access Restriction | Open |
| Subject Keyword | Allergy Airway Asthma Bronchial Hyper-responsiveness Methacholine Challenge Test Season Annals of Thoracic Medicine, Volume 7, Issue 2 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine |
