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Threshold-dependent nonlinear scattering from porphyrin nanobubbles for vascular and extravascular applications
| Content Provider | Scilit |
|---|---|
| Author | Pellow, Carly Acconcia, Christopher N. Zheng, Gang Goertz, David E. |
| Copyright Year | 2018 |
| Description | Journal: Physics in Medicine & Biology Nanobubbles hold potential for expanding utility of ultrasound contrast-based applications to extravascular targets, but their acoustic response and the effects of the surrounding environment remain relatively unexplored. Here we investigate the dynamics of porphyrin-encapsulated nanobubbles (diameter <0.4 µm; 10^6 mL-1) at clinically relevant frequencies (2.5 MHz and 8 MHz) as a function of pressure (0.2 – 1.0 MPa) in vessel- and tissue-mimicking phantoms to gain an understanding of nanobubble behaviour in intra- and extravascular compartments. The results provide the first direct observation that nanobubbles can initiate nonlinear scattering, and that they do so in a pressure-dependent manner. It is further demonstrated that while nanobubbles in confining media require higher pressures for nonlinearities and demonstrate reduced scattering, they can exhibit sustained and non-destructive cavitation. Bubble models are then used to gain mechanistic insights into experimentally observed nanobubble dynamics and confirm sensitivity to nonlinear shell rheology, particularly to radially-dependent surface tension and the characteristic time constant for shear-thinning. |
| Related Links | http://iopscience.iop.org/article/10.1088/1361-6560/aae571/pdf |
| ISSN | 00319155 |
| e-ISSN | 13616560 |
| DOI | 10.1088/1361-6560/aae571 |
| Journal | Physics in Medicine & Biology |
| Issue Number | 21 |
| Volume Number | 63 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physics in Medicine & Biology Acoustics and Ultrasonics Pressure-dependent |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
