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Monte Carlo calculated microdosimetric spread for cell nucleus-sized targets exposed to brachytherapy125I and192Ir sources and60Co cell irradiation
| Content Provider | Scilit |
|---|---|
| Author | Villegas, Fernanda Tilly, Nina Ahnesjö, Anders |
| Copyright Year | 2013 |
| Description | Journal: Physics in Medicine & Biology The stochastic nature of ionizing radiation interactions causes a microdosimetric spread in energy depositions for cell or cell nucleus-sized volumes. The magnitude of the spread may be a confounding factor in dose response analysis. The aim of this work is to give values for the microdosimetric spread for a range of doses imparted by 125I and 192Ir brachytherapy radionuclides, and for a 60Co source. An upgraded version of the Monte Carlo code PENELOPE was used to obtain frequency distributions of specific energy for each of these radiation qualities and for four different cell nucleus-sized volumes. The results demonstrate that the magnitude of the microdosimetric spread increases when the target size decreases or when the energy of the radiation quality is reduced. Frequency distributions calculated according to the formalism of Kellerer and Chmelevsky using full convolution of the Monte Carlo calculated single track frequency distributions confirm that at doses exceeding 0.08 Gy for 125I, 0.1 Gy for 192Ir, and 0.2 Gy for 60Co, the resulting distribution can be accurately approximated with a normal distribution. A parameterization of the width of the distribution as a function of dose and target volume of interest is presented as a convenient form for the use in response modelling or similar contexts. |
| Related Links | http://iopscience.iop.org/0031-9155/58/17/6149/pdf/0031-9155_58_17_6149.pdf |
| Ending Page | 6162 |
| Page Count | 14 |
| Starting Page | 6149 |
| ISSN | 00319155 |
| e-ISSN | 13616560 |
| DOI | 10.1088/0031-9155/58/17/6149 |
| Journal | Physics in Medicine & Biology |
| Issue Number | 17 |
| Volume Number | 58 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2013-09-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physics in Medicine & Biology Nuclear Energy and Engineering Microdosimetric Spread Normal Distribution |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
