NDLI: Integration of iron oxide nanoparticles and polyaspartamide biopolymer for MRI image contrast enhancement and an efficient drug-delivery system in cancer therapy

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Integration of iron oxide nanoparticles and polyaspartamide biopolymer for MRI image contrast enhancement and an efficient drug-delivery system in cancer therapy

Content Provider	Scilit
Author	Nguyen, Minh Phuong Thuy, Van Tran Thi Kim, Dukjoon
Copyright Year	2020
Description	Journal: Nanotechnology We integrate superparamagnetic iron oxide nanoparticles (SPIONs) with polyaspartamide (PA) biopolymer into a bio-constitution that functions as a tracking, targeting, and drug-delivery system for cancer diagnosis and therapy. Iron oxide nanoparticles with uniformly distributed average spherical diameters of around 10 nm and superparamagnetic characteristic, play a key role in increasing the transverse 1/T2 relaxation rate or darkening the T2-weighted MR image for cancer diagnosis using MRI. In in vitro MRI testing on cancer cells, the MR image of samples with the constitution shows a much clearer contrast effect than that of the control. PA biopolymer plays an essential role in enhancing the hydrophilic and biocompatible ability of the constitution. In addition, as a multifunctional polymer, PA is conjugated with biotin and Dox functional groups to enhance targeting and impairment of cancer cells. In in vivo testing on cancer tumor, the magnitude of cancer tumor volume growth injected with the constitution decreases 3 times, compared with that of the control without injection. The physicochemical characteristics of the constitution and the roles of biotin and Dox functional groups are conducted and discussed in detail.
Related Links	https://iopscience.iop.org/article/10.1088/1361-6528/ab8f49/pdf
ISSN	09574484
e-ISSN	13616528
DOI	10.1088/1361-6528/ab8f49
Journal	Nanotechnology
Issue Number	33
Volume Number	31
Language	English
Publisher	IOP Publishing
Publisher Date	2020-05-01
Access Restriction	Open
Subject Keyword	Journal: Nanotechnology Magnetic Resonance Imaging Superparamagnetic Iron Oxide Nanoparticles
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering

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