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Design of a californium-based epithermal neutron beam for neutron capture therapy
| Content Provider | Scilit |
|---|---|
| Author | Yanch, J. C. Kim, J. K. Wilson, M. J. |
| Copyright Year | 1993 |
| Description | Journal: Physics in Medicine & Biology The potential of the spontaneously fissioning isotope,$ ^{252}$Cf, to provide epithermal neutrons for use in boron neutron capture therapy (BNCT) has been investigated using Monte Carlo simulation. The Monte Carlo code MCNP was used to design an assembly composed of a 26 cm long, 11 cm radius cylindrical $D_{2}$O moderator followed by a 64 cm long Al filter. Lithium filters are placed between the moderator and the filter and between the Al and the patient. A reflector surrounding the moderator/filter assembly is required in order to maintain adequate therapy flux at the patient position. An ellipsoidal phantom composed of skull- and brain-equivalent material was used to determine the dosimetric effect of this beam. It was found that both advantage depths and advantage ratios compare very favourably with reactor and accelerator epithermal neutron sources. The dose rate obtainable, on the other hand, is 4.1 RBE cGy $min^{-1}$, based on a very large (1.0 g) source of$ ^{252}$Cf. This dose rate is two to five times lower than those provided by existing reactor beams and can be viewed as a drawback of using$ ^{252}$Cf as a neutron source. |
| Related Links | http://iopscience.iop.org/article/10.1088/0031-9155/38/8/013/pdf |
| Ending Page | 1155 |
| Page Count | 11 |
| Starting Page | 1145 |
| ISSN | 00319155 |
| e-ISSN | 13616560 |
| DOI | 10.1088/0031-9155/38/8/013 |
| Journal | Physics in Medicine & Biology |
| Issue Number | 8 |
| Volume Number | 38 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 1993-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Physics in Medicine & Biology Nuclear Energy and Engineering Epithermal Neutron Neutron Capture Therapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
