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Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model
| Content Provider | Scilit |
|---|---|
| Author | Ménard, Mathilde Meyer, Florent Affolter-Zbaraszczuk, Christine Rabineau, Morgane Adam, Alexandre Ramirez, Paula Duenas Bégin-Colin, Sylvie Mertz, Damien |
| Copyright Year | 2019 |
| Description | Journal: Nanotechnology In this work, we describe the design and the use of a novel theranostic hybrid nanocomposite made of an iron oxide core and a mesoporous silica shell (IO@MS) of ca. 30 nm coated by human serum albumin (HSA) layer for magnetic resonance imaging (MRI) and drug delivery applications. The porosity of IO@MS nanoparticles was loaded with an antitumoral drug, Doxorubicin (Dox) reaching a high drug loading capacity (DLC) of 34w%. To entrap the drug, a tight HSA coating held via isobutyramide (IBAM) binders was deposited. We show that this protein nanoassembly entraps the drugs efficiently and behaves as an innovative enzyme-sensitive gatekeeper that is degraded upon protease action. Finally we assess the Dox release in a 3D cell model via confocal imaging and its cytotoxicity is shown by growth inhibition studies on liver cancer cell spheroids. |
| Related Links | http://iopscience.iop.org/article/10.1088/1361-6528/aafe1c/pdf |
| ISSN | 09574484 |
| e-ISSN | 13616528 |
| DOI | 10.1088/1361-6528/aafe1c |
| Journal | Nanotechnology |
| Issue Number | 17 |
| Volume Number | 30 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2019-01-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanotechnology 3d Spheroid Model Drug Releasing Magnetic Platforms Magnetic Nanocomposites |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering |
