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Mechanically-compliant intracortical implants reduce the neuroinflammatory response
| Content Provider | Scilit |
|---|---|
| Author | Nguyen, Jessica K. Park, Daniel J. Skousen, John L. Hess-Dunning, Allison E. Tyler, Dustin J. Rowan, Stuart J. Weder, Christoph Capadona, Jeffrey R. |
| Copyright Year | 2014 |
| Description | Journal: Journal of Neural Engineering The mechanisms underlying intracortical microelectrode encapsulation and failure are not well understood. A leading hypothesis implicates the role of the mechanical mismatch between rigid implant materials and the much softer brain tissue. Previous work has established the benefits of compliant materials on reducing early neuroinflammatory events. However, recent studies established late onset of a disease-like neurodegenerative state. In this study, we implanted mechanically-adaptive materials, which are initially rigid but become compliant after implantation, to investigate the long-term chronic neuroinflammatory response to compliant intracortical microelectrodes. Three days after implantation, during the acute healing phase of the response, the tissue response to the compliant implants was statistically similar to that of chemically matched stiff implants with much higher rigidity. However, at two, eight, and sixteen weeks post-implantation in the rat cortex, the compliant implants demonstrated a significantly reduced neuroinflammatory response when compared to stiff reference materials. Chronically implanted compliant materials also exhibited a more stable blood-brain barrier than the stiff reference materials. Overall, the data show strikingly that mechanically-compliant intracortical implants can reduce the neuroinflammatory response in comparison to stiffer systems. |
| Related Links | http://europepmc.org/articles/pmc4175058?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175058/pdf |
| Ending Page | 056014 |
| Page Count | 1 |
| Starting Page | 056014 |
| ISSN | 17412560 |
| e-ISSN | 17412552 |
| DOI | 10.1088/1741-2560/11/5/056014 |
| Journal | Journal of Neural Engineering |
| Issue Number | 5 |
| Volume Number | 11 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2014-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neural Engineering Biomimetic Material Intracortical Microelectrode Foreign Body Response Mechanical Properties |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cellular and Molecular Neuroscience Biomedical Engineering |
