NDLI: Wireless opto-electro neural interface for experiments with small freely behaving animals

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Wireless opto-electro neural interface for experiments with small freely behaving animals

Content Provider	Scilit
Author	Jia, Yaoyao Khan, Wasif Lee, Byunghun Fan, Bin Madi, Fatma Weber, Arthur Li, Wen Ghovanloo, Maysam
Copyright Year	2018
Description	Journal: Journal of Neural Engineering Objective. We have developed a wireless opto-electro interface (WOENI) device, which combines electrocorticogram (ECoG) recording and optical stimulation for bi-directional neuromodulation on small, freely behaving animals, such as rodents. Approach. The device is comprised of two components, a detachable headstage and an implantable polyimide-based substrate. The headstage establishes a Bluetooth Low Energy (BLE) bi-directional data communication with an external custom-designed USB dongle for receiving user commands and optogenetic stimulation patterns, and sending digitalized ECoG data. Main results. The functionality and stability of the device were evaluated in vivo on freely behaving rats. When the animal received optical stimulation on the primary visual cortex (V1) and visual stimulation via eyes, spontaneous changes in ECoG signals were recorded from both left and right V1 during 4 consecutive experiments with 7-day intervals over a time span of 21 days following device implantation. Immunostained tissue analyses showed results consistent with ECoG analyses, validating the efficacy of optical stimulation to upregulate the activity of cortical neurons expressing ChR2. Significance. The proposed WOENI device is potentially a versatile tool in the studies that involve long-term optogenetic neuromodulation.
Related Links	http://iopscience.iop.org/article/10.1088/1741-2552/aac810/pdf
ISSN	17412560
e-ISSN	17412552
DOI	10.1088/1741-2552/aac810
Journal	Journal of Neural Engineering
Issue Number	4
Volume Number	15
Language	English
Publisher	IOP Publishing
Publisher Date	2018-05-25
Access Restriction	Open
Subject Keyword	Journal: Journal of Neural Engineering Medical Informatics Ecog Recording Optical Stimulation On V1 Small Freely Behaving Animals Visual Stimulation Wireless Opto-electro Neural Interface (woeni)
Content Type	Text
Resource Type	Article
Subject	Cellular and Molecular Neuroscience Biomedical Engineering

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