NDLI: Development of chitosan graft pluronic$ ^{®}$ F127 copolymer nanoparticles containing DNA aptamer for paclitaxel delivery to treat breast cancer cells

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Development of chitosan graft pluronic$ ^{®}$ F127 copolymer nanoparticles containing DNA aptamer for paclitaxel delivery to treat breast cancer cells

Content Provider	Scilit
Author	Nguyen, Kim Thach Le, Duc Vinh Do, Dinh Ho Le, Quang Huan
Copyright Year	2016
Description	Journal: Advances in Natural Sciences: Nanoscience and Nanotechnology HER-2/ErbB2/Neu(HER-2), a member of the epidermal growth factor receptor family, is specifically overexpressed on the surface of breast cancer cells and serves a therapeutic target for breast cancer. In this study, we aimed to isolate DNA aptamer (Ap) that specifically bind to a HER-2 overexpressing SK-BR-3 human breast cancer cell line, using SELEX strategy. We developed a novel multifunctional composite micelle with surface modification of Ap for targeted delivery of paclitaxel. This binary mixed system consisting of Ap modified $pluronic^{®}$F127 and chitosan could enhance PTX loading capacity and increase micelle stability. Polymeric micelles had a spherical shape and were self-assemblies of block copolymers of approximately 86.22 ± 1.45 nm diameter. PTX could be loaded with high encapsulation efficiency (83.28 ± 0.13%) and loading capacity (9.12 ± 0.34%). The release profile were 29%–35% in the first 12 h and 85%–93% after 12 d at pH 7.5 of receiving media. The $IC_{50}$ doses by MTT assay showed the greater activity of nanoparticles loaded paclitaxel over free paclitaxel and killed cells up to 95% after 6 h. These results demonstrated unique assembly with the capacity to function as an efficient detection and delivery vehicle in the biological living system.
Related Links	http://iopscience.iop.org/article/10.1088/2043-6262/7/2/025018/pdf
ISSN	20436254
e-ISSN	20436262
DOI	10.1088/2043-6262/7/2/025018
Journal	Advances in Natural Sciences: Nanoscience and Nanotechnology
Issue Number	2
Volume Number	7
Language	English
Publisher	IOP Publishing
Publisher Date	2016-06-01
Access Restriction	Open
Subject Keyword	Journal: Advances in Natural Sciences: Nanoscience and Nanotechnology Pharmacology and Pharmacy
Content Type	Text
Resource Type	Article

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