NDLI: TriB-RT: Simultaneous optimization of photon, electron and proton beams

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TriB-RT: Simultaneous optimization of photon, electron and proton beams

Content Provider	Scilit
Author	Kueng, Reto Mueller, Silvan Loebner, Hannes Anton Frei, Daniel Volken, Werner Aebersold, Daniel M. Stampanoni, Marco F. M. Fix, Michael K. Manser, Peter
Copyright Year	2020
Description	Journal: Physics in Medicine & Biology Purpose. To develop a novel treatment planning process (TPP) with simultaneous optimization of modulated photon, electron and proton beams for improved treatment plan quality in radiotherapy. Methods. A framework for fluence map optimization of Monte Carlo (MC) calculated beamlet dose distributions is developed to generate treatment plans consisting of photon, electron and spot scanning proton fields. Initially, in-house intensity modulated proton therapy (IMPT) plans are compared to proton plans created by a commercial treatment planning system (TPS). A triple beam radiotherapy (TriB-RT) plan is generated for an exemplary academic case and the dose contributions of the three particle types are investigated. To investigate the dosimetric potential, a TriB-RT plan is compared to an in-house IMPT plan for two clinically motivated cases. Benefits of TriB-RT for a fixed proton beam line with a single proton field are investigated. Results. In-house optimized IMPT are of at least equal or better quality than TPS-generated proton plans, and MC-based optimization shows dosimetric advantages for inhomogeneous situations. Concerning TriB-RT, for the academic case, the resulting plan shows substantial contribution of all particle types. For the clinically motivated case, improved sparing of organs at risk close to the target volume is achieved compared to IMPT (e.g. myelon and brainstem $Dmax −37%) at cost of an increased low dose bath (healthy tissue V$ _{10%}$ +22%). In the scenario of a fixed proton beam line, TriB-RT plans are able to compensate the loss in degrees of freedom to substantially improve plan quality compared to a single field proton plan. Conclusion. A novel TPP which simultaneously optimizes photon, electron and proton beams was successfully developed. TriB-RT shows the potential for improved treatment plan quality and is especially promising for cost-effective single-room proton solutions with a fixed beamline in combination with a conventional linac delivering photon and electron fields.$
Related Links	https://iopscience.iop.org/article/10.1088/1361-6560/ab936f/pdf
ISSN	00319155
e-ISSN	13616560
DOI	10.1088/1361-6560/ab936f
Journal	Physics in Medicine & Biology
Issue Number	4
Volume Number	66
Language	English
Publisher	IOP Publishing
Publisher Date	2021-02-21
Access Restriction	Open
Subject Keyword	Journal: Physics in Medicine & Biology Radiology, Nuclear Medicine and Imaging Triple Beam Radiotherapy Simultaneous Optimization
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology

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