NDLI: The impact of instilled carbide nanoparticles on rat lungs: anin vivoperspective on acute intratracheal instillation

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The impact of instilled carbide nanoparticles on rat lungs: anin vivoperspective on acute intratracheal instillation

Content Provider	Scilit
Author	Lozano, O. Lison, D. Escamilla-Rivera, Vicente Mejía, J. Toussaint, O. Dogné, J. M. Lucas, S.
Copyright Year	2015
Description	Journal: Journal of Physics: Conference Series In order to study a scenario of acute high concentration exposure via the pulmonary pathway of silicon carbide and titanium carbide nanoparticles, female Wistar rats were administered by intratracheal instillation doses of 0.5 and 5 mg/rat of each nanomaterial. Inflammatory parameters were studied: protein concentration, lactate dehydrogenase activity, total cell count and differentiated cell count (macrophages, neutrophils, oesonophils, lymphocytes). The genotoxicity potential was assessed by the formation of micronuclei from pneumocytes type II. It was found that silicon carbide nanoparticles induce an inflammatory response and a dose dependent genotoxicity, although the genotoxicity levels are comparably lower to the inflammatory response.
Related Links	http://iopscience.iop.org/article/10.1088/1742-6596/617/1/012017/pdf
ISSN	17426588
e-ISSN	17426596
DOI	10.1088/1742-6596/617/1/012017
Journal	Journal of Physics: Conference Series
Issue Number	1
Volume Number	617
Language	English
Publisher	IOP Publishing
Publisher Date	2015-05-26
Access Restriction	Open
Subject Keyword	Journal: Journal of Physics: Conference Series Intratracheal Instillation Rat Lungs Acute Intratracheal Vivo Perspective Carbide Nanoparticles Instilled Carbide
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy

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