NDLI: Biofunctionalized microbead arrays for early diagnosis of breast cancer

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Biofunctionalized microbead arrays for early diagnosis of breast cancer

Content Provider	Scilit
Author	Vafajoo, Atieh Salarian, Reza Rabiee, Navid
Copyright Year	2018
Description	Journal: Biomedical Physics & Engineering Express A high-performance method is suspension microbead arrays which facilitate HER2 recognition for rapid prognosis in its preliminary stages before cancer reaches to its metastases level or first prevalence of tumor growth. To achieve this goal, we synthesized gelatin microbeads by oil in water (o/w) emulsion method and the size and stability of micro-particles were optimized with different concentrations of glutaraldehyde. The non-toxicity of microbeads was proved by MTT assay. Then the Herceptin was immobilized on the microbeads surface by carbodiimide coupling method. FITC was used as a fluorescent marker for recognizing HER2 receptors on SKBr3 cancer cells (clinical sample) and the recognition was tracked by flow cytometry. Results showed significant discrimination between SKBr3 cancer cells sample concerning HER2 negative cancer cells as a control sample.
Related Links	http://iopscience.iop.org/article/10.1088/2057-1976/aae6c1/pdf
ISSN	20571976
e-ISSN	20571976
DOI	10.1088/2057-1976/aae6c1
Journal	Biomedical Physics & Engineering Express
Issue Number	6
Volume Number	4
Language	English
Publisher	IOP Publishing
Publisher Date	2018-10-08
Access Restriction	Open
Subject Keyword	Journal: Biomedical Physics & Engineering Express
Content Type	Text
Resource Type	Article
Subject	Physiology Radiology, Nuclear Medicine and Imaging Biomaterials Biophysics Bioengineering Biomedical Engineering Health Informatics Computer Science Applications

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