NDLI: Gold decorated porous biosilica nanodevices for advanced medicine

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Gold decorated porous biosilica nanodevices for advanced medicine

Content Provider	Scilit
Author	Terracciano, Monica Napolitano, Michela Stefano, Luca De Luca, Anna Chiara De Rea, Ilaria
Copyright Year	2018
Description	Journal: Nanotechnology Diatomite is a fossil material made of amorphous porous silica. In this work, polyethylene glycol (PEG)-modified diatomite NPs (PEG-DNPs) are decorated with gold NPs (AuNPs) by one-pot liquid-phase synthesis. Nanocomplexes (PEG-DNPs@AuNPs), with an average size of about 450 nm, are characterized by dynamic light scattering, electron microscopy, nitrogen adsorption/desorption analysis, UV-VIS and photoluminescence spectroscopies. Preliminary studies on the use of the nanocomplex in nanomedicine are also presented. Tests performed incubating PEG-DNPs@AuNPs in physiological conditions reveal a good stability of material. Cellular uptake of labeled PEG-DNPs@AuNPs is investigated by confocal microscopy after incubation with human cervix epithelioid carcinoma (HeLa) cells up to 48 h: an efficient cytoplasmic localization is observed. In vitro cytotoxicity of nanocomplexes with a concentration up to 400 μg/mL for 72 h is also evaluated. The results suggest the use of PEG-DNPs@AuNPs as advanced nanodevices adding imaging features to the nanocomplexes, due to AuNPs as contrast agent.
Related Links	http://iopscience.iop.org/article/10.1088/1361-6528/aab7c4/pdf
ISSN	09574484
e-ISSN	13616528
DOI	10.1088/1361-6528/aab7c4
Journal	Nanotechnology
Issue Number	23
Volume Number	29
Language	English
Publisher	IOP Publishing
Publisher Date	2018-03-19
Access Restriction	Open
Subject Keyword	Journal: Nanotechnology Gold Nanoparticles Surface Modification
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering

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