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Magnetite nanoparticle interactions with insulin amyloid fibrils
| Content Provider | Scilit |
|---|---|
| Author | Chen, Yun-Wen Chang, Chiung-Wen Hung, Huey-Shan Kung, Mei-Lang Yeh, Bi-Wen Hsieh, Shuchen |
| Copyright Year | 2016 |
| Description | Journal: Nanotechnology Accumulation of amyloid fibrils is one of the likely key factors leading to the development of Alzheimer's disease and other amyloidosis associated diseases. Magnetic nanoparticles (NPs) have been developed as promising medical materials for many medical applications. In this study, we have explored the effects of $Fe_{3}O_{4}$ NPs on the fibrillogenesis process of insulin fibrils. When $Fe_{3}O_{4}$ NPs were co-incubated with insulin, $Fe_{3}O_{4}$ NPs had no effect on the structural transformation into amyloid-like fibrils but had higher affinity toward insulin fibrils. We demonstrated that the zeta potential of insulin fibrils and $Fe_{3}O_{4}$ NPs were both positive, suggesting the binding forces between $Fe_{3}O_{4}$ NPs and insulin fibrils were van der Waals forces but not surface charge. Moreover, a different amount of $Fe_{3}O_{4}$ NPs added had no effect on secondary structural changes of insulin fibrils. These results propose the potential use of $Fe_{3}O_{4}$ NPs as therapeutic agents against diseases related to protein aggregation or contrast agents for magnetic resonance imaging. |
| Related Links | http://iopscience.iop.org/article/10.1088/0957-4484/27/41/415702/pdf |
| Ending Page | 415702 |
| Page Count | 1 |
| Starting Page | 415702 |
| ISSN | 09574484 |
| e-ISSN | 13616528 |
| DOI | 10.1088/0957-4484/27/41/415702 |
| Journal | Nanotechnology |
| Issue Number | 41 |
| Volume Number | 27 |
| Language | English |
| Publisher | IOP Publishing |
| Publisher Date | 2016-09-02 |
| Access Restriction | Open |
| Subject Keyword | Journal: Nanotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Mechanics of Materials Mechanical Engineering Bioengineering Electrical and Electronic Engineering |
