Recovery of platelet factor 4 (PF-4) and beta-thromboglobulin (beta-TG) plasma concentrations during remission in patients suffering from atopic dermatitis

Content Provider	Scilit
Author	Alicja, Kasperska-Zajac
Copyright Year	2010
Description	Journal: Platelets Our previous study has for the first time demonstrated that atopic dermatitis (AD) patients show enhanced plasma concentrations of PF4 and beta-TG. In addition, it has been suggested that chemokines may be the markers of AD severity. The aim of this study was to determine whether enhanced platelet activation in active AD withdraws when the disease reaches the clinical remission stage. Plasma PF-4 and beta-TG concentrations were studied in 10 AD patients and in 23 healthy controls. Patients were examined twice: first, during the active period, and next, during the clinical remission lasting for at least 6 months. Plasma PF-4 and beta-TG concentrations in patients upon AD remission were significantly lower as compared to active AD and did not differ significantly from the healthy subjects. Enhanced platelet activation is a transient phenomenon accompanying active AD and disappears during clinical remission. As with earlier data, the findings point to platelet activity in AD increasing during flare, falling following therapy and normalizing upon remission.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/09537104.2010.493247
Ending Page	524
Page Count	3
Starting Page	522
ISSN	09537104
e-ISSN	13691635
DOI	10.3109/09537104.2010.493247
Journal	Platelets
Issue Number	7
Volume Number	21
Language	English
Publisher	Informa UK Limited
Publisher Date	2010-07-29
Access Restriction	Open
Subject Keyword	Journal: Platelets Beta Tg Atopic Dermatitis Active Ad Clinical Remission Platelet Activation
Content Type	Text
Subject	Hematology