NDLI: Study of DHPS and DHFR genes ofPneumocystis jiroveciiin Thai HIV-infected patients

Please wait, while we are loading the content...

Study of DHPS and DHFR genes ofPneumocystis jiroveciiin Thai HIV-infected patients

Content Provider	Scilit
Author	Siripattanapipong, Suradej Leelayoova, Saovanee Mungthin, Mathirut Worapong, Jeerapun Tan-Ariya, Peerapan
Copyright Year	2008
Description	Journal: Medical mycology The combination of trimethoprim-sulfamethoxazole is widely used for the prophylaxis and treatment of Pneumocystis pneumonia (PCP) caused by Pneumocystis jirovecii. Many studies have shown that mutations in the drug target, the dihydropteroate synthase (DHPS) gene, are presumably involved with the failure of prophylaxis and treatment. We have analyzed dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) mutations in P. jirovecii isolates recovered from Thai patients. Out of 17 samples, 11.7% (2) of the DHPS gene contained a double mutation at codon 55 and codon 57, whereas out of 18 samples, 61.1% (11) of the DHFR genes contained the silent mutation at codon 104. In comparison to previous reports, we have found a higher number of DHFR mutations but a lower prevalence of DHPS mutations.
Related Links	https://academic.oup.com/mmy/article-pdf/46/4/389/2900455/46-4-389.pdf
Ending Page	392
Page Count	4
Starting Page	389
ISSN	13693786
DOI	10.1080/13693780701883722
Journal	Medical mycology
Issue Number	4
Volume Number	46
Language	English
Publisher	Informa UK Limited
Publisher Date	2008-01-01
Access Restriction	Open
Subject Keyword	Journal: Medical mycology Parasitology Dihydrofolate Reductase Pneumocystis Jiroveci Hiv Infections Trimethoprim-sulfamethoxazole Combination Codon Nucleotides Silent Mutations Dihydropteroate Synthase Drug Delivery Systems
Content Type	Text
Subject	Infectious Diseases Veterinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.

High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy.

Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.

Pneumocystis jirovecii Infection and the Associated Dihydropteroate Synthase (DHPS) and Dihydrofolate Reductase (DHFR) Mutations in HIV-Positive Individuals from Pune, India

Pneumocystis carinii Dihydropteroate Synthase but Not Dihydrofolate Reductase Gene Mutations Correlate with Prior Trimethoprim-Sulfamethoxazole or Dapsone Use

Study of dihydropteroate synthase (DHPS) gene mutations among isolates of Pneumocystis jiroveci.

Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyremethamine in single-drug and combination therapy of uncomplicated malaria in Uganda (2004)

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy

Study of DHPS and DHFR genes ofPneumocystis jiroveciiin Thai HIV-infected patients

Similar Documents

Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.

High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy.

Dihydropteroate synthase (DHPS) gene mutation study in HIV-Infected Indian patients with Pneumocystis jirovecii pneumonia.

Pneumocystis jirovecii Infection and the Associated Dihydropteroate Synthase (DHPS) and Dihydrofolate Reductase (DHFR) Mutations in HIV-Positive Individuals from Pune, India

Pneumocystis carinii Dihydropteroate Synthase but Not Dihydrofolate Reductase Gene Mutations Correlate with Prior Trimethoprim-Sulfamethoxazole or Dapsone Use

Study of dihydropteroate synthase (DHPS) gene mutations among isolates of Pneumocystis jiroveci.

Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyremethamine in single-drug and combination therapy of uncomplicated malaria in Uganda (2004)

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy

Genetic mutations in Plasmodium falciparum and Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) in Vanuatu and Solomon Islands prior to the introduction of artemisinin combination therapy

Study of DHPS and DHFR genes ofPneumocystis jiroveciiin Thai HIV-infected patients