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Circannual Rhythm of Insulin Release and Hypoglycemic Effect of Tolbutamide Stimulus in Healthy Man
| Content Provider | Scilit |
|---|---|
| Author | Ponte, A. Del Guagnano, M. T. Sensi, S. |
| Copyright Year | 1984 |
| Description | Journal: Chronobiology international Four healthy non obese young volunteers were observed for a 24-hr period, every other month, over the course of one year. Tolbutamide was injected i.v. each day of the experiment every four hours. Tolbutamide-induced insulin secretion (T.I.I.S.) was evaluated by planimetrically measuring insulin areas above basal levels. Tolbutamide-induced hypoglycemic effect was evaluated by measuring the blood glucose difference between the Sth and 25th minute after the drug injection (δG 5′-25′). The macroscopic evaluation of T.I.I.S. and δG 5′-2S′(mean chronograms) permitted the detection of the existence of a circannual variation of both variables. In particular the maximum level of the blood glucose drop (δG 5-25) was registered in February. Subsequently the quantification of the rhythm of T.I.I.S. was obtained by fitting a sine curve, according to the Cosinor method. The highest insulin release was confirmed in winter. As previously documented, the existence of a statistically significant circadian rhythm of T.I.I.S. was confirmed in the morning, i.e. the same period of the day in which insulin-induced hypoglycemia occurs. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/07420528409063899 |
| Ending Page | 228 |
| Page Count | 4 |
| Starting Page | 225 |
| ISSN | 07420528 |
| e-ISSN | 15256073 |
| DOI | 10.3109/07420528409063899 |
| Journal | Chronobiology international |
| Issue Number | 3 |
| Volume Number | 1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1984-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chronobiology international Endocrinology and Metabolism Healthy Man Circannual Rhythm Hypoglycemic Effect Tolbutamide Stimulus Insulin Release |
| Content Type | Text |
| Subject | Physiology Physiology (medical) |
