NDLI: Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth

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Green Synthesized BSA-Coated Selenium Nanoparticles Inhibit Bacterial Growth While Promoting Mammalian Cell Growth

Content Provider	Scilit
Author	Chung, Stanley Zhou, Renhui Webster, Thomas J.
Copyright Year	2020
Description	Journal: International Journal of Nanomedicine Background: Selenium is an essential trace element that is critical for many biological processes. Selenium nanoparticles (SeNPs) have shown more promise than other forms of selenium due to their low cytotoxicity and high bioavailability. Methods: In this work, a one-step method was demonstrated for fabricating bovine serum albumin (BSA) stabilized SeNPs using ascorbic acid as the reductant. Human dermal fibroblasts were used to assess mammalian cytotoxicity, and Staphylococcus aureus and Escherichia coli were used to assess antibacterial performance. Results: These SeNPs demonstrated increased fibroblast growth and reduced Staphylococcus aureus growth with a fibroblast $IC_{50}$ value (>681 μg/mL) 1 order of magnitude higher than that for bacteria at day 1. Conclusion: This study demonstrated the promise of this synthesis process in achieving controllable selenium nanoparticle sizes without the use of strong basic solvents for improved antibacterial properties.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955603/pdf https://www.dovepress.com/getfile.php?fileID=55205
Ending Page	124
Page Count	10
Starting Page	115
e-ISSN	11782013
DOI	10.2147/IJN.S193886
Journal	International Journal of Nanomedicine
Volume Number	ume 15
Language	English
Publisher	Informa UK Limited
Publisher Date	2020-01-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Integrative and Complementary Medicine Antibacterial Ascorbic Acid Green Synthesis Nanoparticles
Content Type	Text

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