NDLI: Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression

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Clear cell ovarian cancers with microsatellite instability: A unique subset of ovarian cancers with increased tumor-infiltrating lymphocytes and PD-1/PD-L1 expression

Content Provider	Scilit
Author	D'Andrea, Alan D. Howitt, Brooke E. Strickland, Kyle C. Sholl, Lynette M. Rodig, Scott Ritterhouse, Lauren L. Chowdhury, Dipanjan Matulonis, Ursula A. Konstantinopoulos, Panagiotis A.
Copyright Year	2017
Description	Journal: OncoImmunology Clear cell ovarian carcinoma (CCOC) represents a distinct histologic subtype of ovarian cancer associated with significantly worse prognosis across all stages and no effective therapeutic options. Here, we report a rare but clinically important cohort of CCOCs with microsatellite instability (MSI) (MSI-CCOCs), which are highly immunogenic and may thus be very responsive to immune checkpoint blockade. CCOCs with MSI exhibit a significantly higher number of $CD8^{+}$ TILs, higher $CD8^{+}/CD4^{+}$ ratio, and higher $PD-1^{+}$ TILs compared with microsatellite stable (MSS) CCOCs and compared with high grade serous ovarian cancers, which are the most common histologic subtype of ovarian cancer. Of note, PD-L1 expression in tumor cells or immune cells was noted in all cases of CCOCs with MSI. These observations open an alternative therapeutic avenue for a fraction of patients with CCOC and argue for the routine testing of CCOCs for MSI, a test that is not currently routinely performed.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/2162402X.2016.1277308?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353914/pdf
e-ISSN	2162402X
DOI	10.1080/2162402x.2016.1277308
Journal	OncoImmunology
Issue Number	2
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-02-01
Access Restriction	Open
Subject Keyword	Journal: OncoImmunology Otorhinolaryngology Clear Cell Ovarian Cancer Immunotherapy Microsatellite Instability Pd-1 Pd-l1 Tumor-infiltrating Lymphocytes
Content Type	Text

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